ChemicalBook CAS DataBase List 2,4-DICHLORO-1-NAPHTHOL

2,4-DICHLORO-1-NAPHTHOL synthesis

9synthesis methods

Product Name:2,4-DICHLORO-1-NAPHTHOL
CAS Number:2050-76-2
Molecular formula:C10H6Cl2O
Molecular Weight:213.06

90-15-3 Synthesis

90-15-3
724 suppliers
$9.00/5g

604-44-4
199 suppliers
$17.46/5G

2050-76-2
87 suppliers
$34.00/5g

Yield:-

Reaction Conditions:

with N-chloro-succinimide;zirconium(IV) chloride in dichloromethane at 0; for 6 h;Conversion of starting material;

Steps:

5
Chlorination using NCS has been found to be applicable for use with a wide range of aromatic starting materials or substrates, as is shown in Table 2. All the substrates treated with 1 equivalent of NCS and 5 mole % of ZrCU afforded the corresponding chlorinated compounds. The reaction at room temperature afforded a high yield of chlorinated product with high regioselectivity. In some cases, a small amount of regioisomers (Entry 3) or dichlorinated products (Entries 4 and 5) were observed.Table 2 ZrCIj Catalyzed Chlorination of Aromatic Compounds by NCS2-CI : 4-CI (13: 87)^b EPO 1 -CI : 1 ,4-di-CI(83: 17)^b^a Reaction conditions. Substrate (0.5 mmol), NCS (0.5 mmol), ZrCI₄ (5 mol %), CH₂CI₂ (4 mL). ^b Determined by ¹H NMR. ^c See spectroscopic data for characterization.

References:

UNIVERSITY OF CHICAGO;JAPAN SCIENCE AND TECHNOLOGY AGENCY WO2007/27917, 2007, A2 Location in patent:Page/Page column 26

90-15-3 Synthesis

90-15-3
724 suppliers
$9.00/5g

2050-76-2
87 suppliers
$34.00/5g