ChemicalBook CAS DataBase List 2-(4-Aminopentyl(ethyl)amino)ethanol

2-(4-Aminopentyl(ethyl)amino)ethanol synthesis

7synthesis methods

Product Name:2-(4-Aminopentyl(ethyl)amino)ethanol
CAS Number:69559-11-1
Molecular formula:C9H22N2O
Molecular Weight:174.28

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69559-11-1
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Yield:69559-11-1 97%

Reaction Conditions:

with nickel in toluene at 70; for 12 h;

Steps:

7 Racemization of (R)-2-[(4-Aminopentyl)ethylamino]ethanol

Weigh 50g (0.287mol) of R-hydroxychloroquine side chain (chemical name: (R)-2-[(4-aminopentyl)ethylamino]ethanol), dissolve it in 290mL of toluene, and add 2.5g of mine Nickel, under normal pressure and hydrogen atmosphere, stirred at 70°C for 12 hours. When the optical rotation of the reaction supernatant is measured to be zero or close to zero, cool, stand, and filter with suction. The filtrate is concentrated to dryness and is colorless. 48.5 grams of oily liquid, which is (±)-2-[(4-aminopentyl)ethylamino]ethanol, with a yield of 97%.

References:

CN111803501,2020,A Location in patent:Paragraph 0120; 0126-0127

74509-79-8 Synthesis