ChemicalBook CAS DataBase List 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine synthesis

7synthesis methods

Product Name:2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine
CAS Number:161599-46-8
Molecular formula:C13H16FN3O6
Molecular Weight:329.28

66335-38-4 Synthesis

66335-38-4
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2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

161599-46-8
450 suppliers
$6.00/250mg

Yield:-

Reaction Conditions:

with acetic anhydride in pyridine;water

Steps:

a (a)
(a) From 5'-deoxy-5-fluorocytidine 5'-Deoxy-5-fluorocytidine (50 mg) was dissolved in dry pyridine (1.3 ml). To the solution was added acetic anhydride (39 ml) with stirring at 0° C. The reaction mixture was stirred for 3 hours at 0° C. After removal of the solvent under reduced pressure, the residue was partitioned between ethyl acetate and ice cooled water. The ethyl acetate layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane/methanol=9/1 as an eluent) followed by recrystallization from isopropanol to give 37 mg of 2',3'-di-O-acetyl-5'-deoxy-5-fluorocytidine: 191.5°-193° C., FAB-MS m/z 330 (MH⁺).

References:

Hoffmann-La Roche Inc. US5472949, 1995, A

2022-85-7 Synthesis