2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRIC ACID ETHYL ESTER synthesis

3synthesis methods

Product Name:2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRIC ACID ETHYL ESTER
CAS Number:86815-10-3
Molecular formula:C10H17NO3
Molecular Weight:199.25

64-17-5 Synthesis

64-17-5
724 suppliers
$10.00/50g

alpha-Ethyl-2-oxo-1-pyrrolidineacetic acid

67118-31-4
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$94.25/1g

2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRIC ACID ETHYL ESTER

86815-10-3
11 suppliers
$175.00/500mg

Yield:86815-10-3 90.1%

Reaction Conditions:

with sulfuric acid at 78 - 80; for 2 h;

Steps:

3 Preparation of α-ethyl-2-oxo-1-pyrrolidine acetate (II)

Add α-ethyl-2-oxo-1-pyrrolidine acetic acid (50g, 0.29mol) to the reaction flaskand ethanol (150g), dropwise added concentrated sulfuric acid (5g), heated to 7880 and refluxed for 2 hours under stirring, added water (100g), controlled the temperature in the range of 4060,Add 15% Na2CO3 solution dropwise until the pH of the reaction system is 7.0-7.5,The remaining ethanol was evaporated under reduced pressure at a temperature of 40-50 °C, and the residual liquid was extracted with dichloromethane (100 g) three times.Combine the organic phases, distill under reduced pressure until no liquid flows out,get Alpha-ethyl-2-oxo-1-pyrrolidine ethyl acetate,Yield 52.4 g, yield 90.1%, HPLC purity 99.3%.

References:

CN113861090,2021,A Location in patent:Paragraph 0039-0041

616-45-5 Synthesis