2-(2,3-DICHLORO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID synthesis
- Product Name:2-(2,3-DICHLORO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID
- CAS Number:257876-07-6
- Molecular formula:C10H5Cl2NO2S
- Molecular Weight:274.12
1113-59-3
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$14.00/1g
84863-83-2
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$17.67/250mgs:
257876-07-6
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$75.00/10mg
Yield:257876-07-6 98%
Reaction Conditions:
in 1,4-dioxane; for 2 h;Product distribution / selectivity;Heating / reflux;
Steps:
D.1
Step 1. 2-(2,3-Dichloro-phenyl)-thiazole-4-carboxylic acid A solution of 2,3-dichloro-thiobenzamide (Maybridge plc, Tintagel, Cornwall, UK; 2.06 g, 10 mmol) and 3-bromopyruvic acid (1.67 g, 10 mmol) in dioxane (50 mL) was heated at reflux for 2 hrs. The solution was concentrated in vacuo. Water (50 mL) was added. The resulting solid was filtered and triturated with ether to give a white solid (2.68 g, 98%).
References:
US2007/167622,2007,A1 Location in patent:Page/Page column 14
175276-86-5
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$179.00/1g
257876-07-6
20 suppliers
$75.00/10mg
5980-24-5
43 suppliers
$31.80/1gm:
257876-07-6
20 suppliers
$75.00/10mg