2-(1H-1,2,3-benzotriazol-5-yl)acetic acid synthesis
- Product Name:2-(1H-1,2,3-benzotriazol-5-yl)acetic acid
- CAS Number:491612-10-3
- Molecular formula:C8H7N3O2
- Molecular Weight:177.16
1246639-99-5
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491612-10-3
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Yield:491612-10-3 56%
Reaction Conditions:
with water;sodium hydroxide in ethanol; for 3 h;Reflux;
Steps:
7.2
7.2 5.7 g (28 mmol) of 22 are dissolved in 25 ml of water and 10 ml of EtOH, and 75 ml of 5% aqueous NaOH solution are added. The mixture is heated under reflux for 3 h. After cooling, the mixture is evaporated in vacuo. The residue is dissolved in 100 ml of water and adjusted to pH 4 using 5-6 N HCl in propanol. The crystals which have precipitated out are filtered off with suction, giving 3.3 g (56%) of 23 as brown crystals.
References:
US2012/15959,2012,A1 Location in patent:Page/Page column 23
85907-78-4
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