ChemicalBook CAS DataBase List 1H-Indazole-5-carbonitrile,7-fluoro-(9CI)

1H-Indazole-5-carbonitrile,7-fluoro-(9CI) synthesis

5synthesis methods

Product Name:1H-Indazole-5-carbonitrile,7-fluoro-(9CI)
CAS Number:633327-24-9
Molecular formula:C8H4FN3
Molecular Weight:161.14

633327-22-7 Synthesis

633327-22-7
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1H-Indazole-5-carbonitrile,7-fluoro-(9CI)

633327-24-9
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: potassium carbonate / 1,2-dimethoxyethane / 12 h / 60 °C
2: hydrazine / tetrahydrofuran / 48 h / 90 °C
3: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C
4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 120 °C

References:

SAVIRA PHARMACEUTICALS GMBH;EUROPEAN MOLECULAR BIOLOGY LABORATORY;TAN, Xuefei;LIU, Yongfu;WU, Jun;ZBINDEN, Katrin Groebke;KUHN, Bernd;TANG, Guozhi;WU, Guolong;WANG, Lisha;SHEN, Hong;SHI, Tianlai;QIU, Zongxing WO2017/133670, 2017, A1

557-21-1 Synthesis