1H-indazole-3-carboxylic acid methyl ester synthesis
- Product Name:1H-indazole-3-carboxylic acid methyl ester
- CAS Number:43120-28-1
- Molecular formula:C9H8N2O2
- Molecular Weight:176.17
Yield:43120-28-1 93%
Reaction Conditions:
Stage #1: methanol;2H-indazole-3-carboxylic acid;sulfuric acid for 16 h;Reflux;
Stage #2: with sodium hydrogencarbonate in water;ethyl acetate;
Steps:
1; A
A solution of 2H-indazole-3-carboxylic acid (5.00 g, 30.8 mmol) and concentrated sulphuric acid (0.16 mL, 3.08 mmol) in methanol (100 mL) was heated to reflux for 16 hours. The reaction mixture was concentrated in vacuo and then partitioned between ethyl acetate and water, washed with saturated sodium bicarbonate solution (aq.), the aqueous phase extracted with ethyl acetate, the combined organic layers washed with brine, dried (magnesium sulfate) and concentrated to give 2.02 g (93%) of the title compound.
References:
US2010/305120,2010,A1 Location in patent:Page/Page column 43
67-56-1
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43120-28-1
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