1H-BENZOTRIAZOLE-1-METHANOL synthesis
- Product Name:1H-BENZOTRIAZOLE-1-METHANOL
- CAS Number:28539-02-8
- Molecular formula:C7H7N3O
- Molecular Weight:149.15
Yield:28539-02-8 94%
Reaction Conditions:
in water at 25; for 0.0833333 h;
Steps:
30
Example 30 1-Hydroxymethyl-1H-benzotriazole [0464] Dissolve 10 g (83.94 mmol) of 1H-benzotriazole in 6.81 mL (83.94 mmol) of a 37% aqueous solution of formaldehyde. Stir and bring the mixture to a temperature of 25° C. After 5 minutes, the reaction mixture solidifies. Cool the solution to ambient temperature. Filter and wash with diethyl ether. Triturate the residue in the cold in tetrahydrofuran and filter (Int. 94). [0465] Yield: 94% [0466] Melting point: 148-150° C. (tetrahydrofuran and diethyl ether)
References:
Le Borgne, Marc;Na, Young Min;Pagniez, Fabrice;Le Baut, Guillaume;Le Pape, Patrice;Abdala, Hiam US2004/67998, 2004, A1 Location in patent:Page/Page column 24
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