ChemicalBook CAS DataBase List ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE

ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE synthesis

5synthesis methods

Product Name:ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE
CAS Number:193827-69-9
Molecular formula:C13H9ClF3NO2
Molecular Weight:303.66

26893-12-9 Synthesis

ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE

26893-12-9
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$20.00/250mg

ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE

193827-69-9
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Yield:193827-69-9 86%

Reaction Conditions:

with trichlorophosphate for 3 h;Reflux;

Steps:

4.1.6. General procedure for synthesis of ethyl 6-unsubtituted/methoxy/fluoro/trifluoromethyl-4-chloroquinoline-3-carboxylate (11a-d)

General procedure: To the corresponding intermediate 10 (25 mmol), POCl3 (125 mmol) was added slowly and refluxed for 3 h at 105 °C. TLC analysis indicated that the reaction was completed. Excess POCl3 was removed under reduced pressure and the crude reaction mass was quenched with crushed ice then neutralized with saturated sodium bicarbonate solution (100 mL) and extracted with ethyl acetate(3*100 mL). The organic layer was dried over anhy. Na2SO4, filtered and evaporated under reduced pressure to get corresponding desired chloro intermediate.

References:

Medapi, Brahmam;Suryadevara, Priyanka;Renuka, Janupally;Sridevi, Jonnalagadda Padma;Yogeeswari, Perumal;Sriram, Dharmarajan [European Journal of Medicinal Chemistry,2015,vol. 103,art. no. 7959,p. 1 - 16]