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190654-78-5

9H-Purin-6-aMine, 2-chloro-N-(3-chlorophenyl)-9-(1-Methylethyl)- synthesis

5synthesis methods
-

Yield:190654-78-5 94%

Reaction Conditions:

Stage #1: 2-chloro-6-(3-chlorophenylamino)-purinewith sodium hydride in N,N-dimethyl-formamide at 20; for 1 h;
Stage #2: 2-iodo-propane in N,N-dimethyl-formamide; for 24 h;

References:

Oh, Chang-Hyun;Kim, Hee-Kwon;Lee, Su-Chul;Oh, Changsok;Yang, Boem-Seok;Rhee, Hak June;Cho, Jung-Hyuck [Archiv der Pharmazie,2001,vol. 334,# 11,p. 345 - 350]