2-Pyrrolidinemethanol, 1-(trifluoroacetyl)-, (2S)- (9CI) synthesis
- Product Name:2-Pyrrolidinemethanol, 1-(trifluoroacetyl)-, (2S)- (9CI)
- CAS Number:186202-18-6
- Molecular formula:C7H10F3NO2
- Molecular Weight:197.15
383-63-1
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Yield:-
Reaction Conditions:
in tetrahydrofuran;
Steps:
B.6.1 1.
(1) Trifluoroacetyl-L-Prolinol (Compound 1) L-prolinol (2.0 g, 20 mmol) was dissolved in 20 ml of THF. On the other hand, ethyl trifluoroacetate (3.0 g, 21 mmol) was dissolved in 20 ml of THF. Then, the latter THF solution was instilled in the former THF solution containing the L-prolinol, and this was stirred for 12 hours. This reaction solution was vacuum concentrated. Thus, Compound 1 was obtained (3.7 g, yield: 97%). The result of NMR analysis with respect to this compound is shown below. 1H-NMR (CDCl3): δ4.28-4.23 (1.0H, m, OH), 3.90-3.41 (5H, H-2, H-5, H-6, m), 2.27-1.77 (4H, H-3, H-4, m).
References:
US2012/10271,2012,A1
23356-96-9
466 suppliers
$11.19/5G
186202-18-6
3 suppliers
inquiry