TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE synthesis
- Product Name:TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
- CAS Number:158985-37-6
- Molecular formula:C16H24N2O3
- Molecular Weight:292.37
158985-36-5
65 suppliers
$25.00/250mg
158985-37-6
62 suppliers
$42.00/250mg
Yield:158985-37-6 98%
Reaction Conditions:
Stage #1: 4-(4-methoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl esterwith diethylzinc;lithium chloride in tetrahydrofuran;hexane at 20; for 6 h;Inert atmosphere;
Stage #2: with sodium hydroxide in tetrahydrofuran;hexane;water at 20; for 8 h;Inert atmosphere;chemoselective reaction;
References:
Kovalenko, Oleksandr O.;Adolfsson, Hans [Chemistry - A European Journal,2015,vol. 21,# 7,p. 2785 - 2788] Location in patent:supporting information
![4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid](/CAS/GIF/162046-66-4.gif)
162046-66-4
139 suppliers
$6.00/250mg
158985-37-6
62 suppliers
$42.00/250mg
197638-83-8
106 suppliers
$7.00/250mg
158985-37-6
62 suppliers
$42.00/250mg