3-(1-((2R,3S,4S,5R)-5-((bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-(tert-butyldiMethylsilyloxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyriMidin-4-ylthio)propanenitrile synthesis

6synthesis methods

Product Name:3-(1-((2R,3S,4S,5R)-5-((bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-(tert-butyldiMethylsilyloxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyriMidin-4-ylthio)propanenitrile
CAS Number:154665-03-9
Molecular formula:C39H47N3O7SSi
Molecular Weight:729.96

58-96-8 Synthesis

58-96-8
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3-(1-((2R,3S,4S,5R)-5-((bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-(tert-butyldiMethylsilyloxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyriMidin-4-ylthio)propanenitrile

154665-03-9
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: acetonitrile / 2 h / Heating
2: Bu₄NBr; aq. Na₂CO₃ / CH₂Cl₂ / 16 h / 20 °C
3: N-methylpyrrolidine / CH₂Cl₂ / 0.5 h / 20 °C
4: CF₃COOH / methanol
5: 5.81 g / pyridine / 20 h / 20 °C
6: 40 percent / imidazole / dimethylformamide / 36 h / 20 °C