ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE synthesis
- Product Name:ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE
- CAS Number:15028-41-8
- Molecular formula:C5H12ClNO2
- Molecular Weight:153.61
62-57-7
438 suppliers
$10.64/25G
15028-41-8
212 suppliers
$9.00/10g
Yield:-
Reaction Conditions:
with thionyl chloride in methanol;diethyl ether
Steps:
3.H 3-((2R)-2-((benzyloxy)amino)-3-(4-bromophenoxy)propyl)-5,5-dimethyl-2,4-imidazolidinedione
EXAMPLE 3H 3-((2R)-2-((benzyloxy)amino)-3-(4-bromophenoxy)propyl)-5,5-dimethyl-2,4-imidazolidinedione A solution of 2-aminoisobutyric acid (51.7 g) in methanol (500 mL) at 0° C. was treated with thionyl chloride (80.4 g) over 35 minutes, stirred for 30 minutes, warmed to room temperature, heated to 50° C. for 3 hours, cooled to room temperature, and concentrated. The concentrate was dissolved in methanol (200 mL), concentrated, dissolved in warm methanol (50 mL), treated with diethyl ether (300 mL), and filtered. The resulting solid was dried under vacuum (100 mm Hg) at 50° C. with a nitrogen bleed to provide 59.6 g of methyl 2-amino-2-methylpropanoate hydrochloride.
References:
Bailey, Anne E.;Hill, David R.;Hsiao, Chi-Nung W.;Kurukulasuriya, Ravi;Wittenberger, Steve;McDermott, Todd;McLaughlin, Maureen A. US2002/19539, 2002, A1
67-56-1
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62-57-7
438 suppliers
$10.64/25G
15028-41-8
212 suppliers
$9.00/10g
84758-55-4
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$39.00/100mg
15028-41-8
212 suppliers
$9.00/10g
62-57-7
438 suppliers
$10.64/25G
74-88-4
349 suppliers
$15.00/10g
15028-41-8
212 suppliers
$9.00/10g