ChemicalBook CAS DataBase List Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate synthesis

7synthesis methods

Product Name:Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate
CAS Number:148901-69-3
Molecular formula:C27H26FNO4
Molecular Weight:447.5

32249-35-7 Synthesis

32249-35-7
214 suppliers
$5.00/5g

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate

148901-69-3
113 suppliers
$98.00/100mg

Yield:-

Steps:

Multi-step reaction with 6 steps
1.1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C
2.1: DIBAL-H / toluene / 2 h / 0 °C
3.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH₂Cl₂ / 1 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C
4.2: tetrahydrofuran; hexane / -78 °C
5.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H₂O / 24 h / 20 °C
6.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C

References:

Suzuki;Iwasaki;Fujikawa;Kitahara;Sakashita;Sakoda [Bioorganic and Medicinal Chemistry,2001,vol. 9,# 10,p. 2727 - 2743]

141-97-9 Synthesis