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Pyrimidine, 4-chloro-6-methoxy-5-nitro-2-(propylthio)- synthesis
- Product Name:Pyrimidine, 4-chloro-6-methoxy-5-nitro-2-(propylthio)-
- CAS Number:1431867-39-8
- Molecular formula:C8H10ClN3O3S
- Molecular Weight:263.7
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145783-14-8
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$11.00/1g
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124-41-4
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$12.00/25g
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1431867-39-8
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Yield:1431867-39-8 79%
Reaction Conditions:
in methanol at 20; for 1 h;
Steps:
5 Example 5
Preparation of 4-chloro-6-methoxy-5-nitro-2-(propylthio)pyrimidine (CMLIN)
To a solution of CLIN (1.0 g, 3.73 mmol) in dry MeOH (10 mL) NaOMe (0.20 g, 3.73 mmol) was slowly added, and reaction mixture was then stirred at room temperature for 1 h. AcOH (1 mL) and water (20 mL) were added, and product was extracted to MeTHF (3 x 10 mL).
Combined organic phases were dried over MgSO4 and concentrated to afford crude product, which was then purified by chromatography (SiO2, hexane:EtOAc) to afford yellow oil (0.78 g, 79% yield). MS (ESI) m/z: 264 [MH]+.
References:
EP2586773,2013,A1 Location in patent:Paragraph 0077-0078