2-Oxazoleethanol, β,5-dibromo-4-[4-(trifluoromethyl)phenyl]-, 2-acetate synthesis

3synthesis methods

Product Name:2-Oxazoleethanol, β,5-dibromo-4-[4-(trifluoromethyl)phenyl]-, 2-acetate
CAS Number:1403883-99-7
Molecular formula:C14H10Br2F3NO3
Molecular Weight:457.04

2-Oxazoleethanol, 5-bromo-4-[4-(trifluoromethyl)phenyl]-, 2-acetate

1403883-98-6
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2-Oxazoleethanol, β,5-dibromo-4-[4-(trifluoromethyl)phenyl]-, 2-acetate

1403883-99-7
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Yield:1403883-99-7 39%

Reaction Conditions:

with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in tetrachloromethane at 80;

Steps:

2.5

To a solution of 2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl acetate (0.325 g, 0.86 mmol), in CC1₄ (15 mL) was added NBS (0.153 g, 0.86 mmol) and AIBN (0.015 g, 0.09 mmol). The resulting reaction mixture was stirred at 80°C for 5-6 h. After the completion of reaction, the mixture was filtered and the filtrate concentrated in vacuo. The residue was purified by flash chromatography (1.0% EtOAc/hexane) to yield 2-bromo-2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2- yl)ethyl acetate (0.155 g, 39%).

References:

WO2012/142671,2012,A1 Location in patent:Page/Page column 31-33

383-53-9 Synthesis

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1403883-99-7
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References

2-Oxazoleacetic acid, 4-[4-(trifluoromethyl)phenyl]-, ethyl ester

1403883-96-4
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1403883-99-7
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References

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2-Oxazoleethanol, β,5-dibromo-4-[4-(trifluoromethyl)phenyl]-, 2-acetate synthesis