Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate synthesis
- Product Name:Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate
- CAS Number:139481-69-9
- Molecular formula:C25H22N6O3
- Molecular Weight:454.48
21606-04-2
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$7.00/1g
139481-69-9
144 suppliers
$8.00/250mg
Yield:-
Steps:
Multi-step reaction with 8 steps
1: SOCl2, DMF / toluene / 0.5 h / Heating
2: NaN3 / acetone; H2O / 1 h
3: 1.5 h / Heating
4: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
6: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
7: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
8: 100 percent / trimethyltin azide / toluene / 29 h / Heating
References:
Kubo, Keiji;Kohara, Yasuhisa;Imamiya, Eiko;Sugiura, Yoshihiro;Inada, Yoshiyuki;et al. [Journal of Medicinal Chemistry,1993,vol. 36,# 15,p. 2182 - 2195]
![Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate](/CAS/GIF/139481-44-0.gif)
139481-44-0
328 suppliers
$9.00/5g
139481-69-9
144 suppliers
$8.00/250mg
73833-13-3
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139481-69-9
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603-11-2
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$15.00/25 g
139481-69-9
144 suppliers
$8.00/250mg
![BENZOIC ACID, 2-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-3-NITRO-METHYL ESTER](/CAS/GIF/57113-90-3.gif)
57113-90-3
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$165.00/50mg
139481-69-9
144 suppliers
$8.00/250mg