5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile synthesis
- Product Name:5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile
- CAS Number:1338365-54-0
- Molecular formula:C22H25N3O2
- Molecular Weight:363.45
![1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile](/CAS/GIF/350797-56-7.gif)
350797-56-7
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Yield: 97.1%
Reaction Conditions:
with hydrogenchloride;zinc in ethanol;water at 30; for 15 h;Temperature;Concentration;
Steps:
2
General procedure: Raw materials (II), hydrochloric acid added to the organic solvent, heated to a certain temperature, slowly adding zinc powder in batch, by thin layer chromatography (TLC) or high performance liquid chromatography (HPLC) to the raw material (II) completely react , The filter cake is washed with a solvent to the product (I), and then subjected to separation and purification by conventional means such as concentration, washing, drying,To give the salt of the compound (I), which is obtained by alkalizing the free base of (I).
References:
Changzhou Ruiming Pharmaceutical Co., Ltd.;Shi Weiming CN106928118, 2017, A Location in patent:Paragraph 0014; 0020-0024
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![1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde](/CAS/20180702/GIF/350797-55-6.gif)
350797-55-6
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