成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 9-broMo-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
1256579-62-0

9-broMo-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile synthesis

3synthesis methods
9-broMo-3-cyano-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl trifluoroMethanesulfonate

1256579-48-2
4 suppliers
inquiry

53617-35-9 Synthesis
4-Morpholinopiperidine

53617-35-9
246 suppliers
$10.00/1g

9-broMo-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

1256579-62-0
6 suppliers
inquiry

-

Yield:1256579-62-0 98%

Reaction Conditions:

in 1-methyl-pyrrolidin-2-one at 120; for 3 h;

Steps:

5.1.22. 9-Bromo-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile(16)

To a solution of 11 (737 mg, 1.43 mmol) in NMP (12 mL) was added 4-morpholinopiperidine (1.05 g, 6.17 mmol). After stirring for 3 h at 120 °C, the reaction mixture was cooled and poured into water to afford precipitation. The precipitate was filtered off and dried under reduced pressure to yield 16 as a white solid(748 mg, 98%). 1H NMR (400 MHz, DMSO-d6) δ: 8.24-8.30 (2H, m), 8.00 (1H, s), 7.59 (1H, d, J = 8.2 Hz), 7.42 (1H, s), 3.45-3.66 (6H, m), 2.80 (2H, t, J = 11.1 Hz), 2.28-2.38 (1H, m), 1.87-1.96 (2H, m), 1.75 (6H, s), 1.56-1.66 (2H, m); HRMS (ESI), m/z Calcd for C28H29BrN4O2+H: 533.1547, Found: 533.1546.

References:

Kinoshita, Kazutomo;Asoh, Kohsuke;Furuichi, Noriyuki;Ito, Toshiya;Kawada, Hatsuo;Hara, Sousuke;Ohwada, Jun;Miyagi, Takuho;Kobayashi, Takamitsu;Takanashi, Kenji;Tsukaguchi, Toshiyuki;Sakamoto, Hiroshi;Tsukuda, Takuo;Oikawa, Nobuhiro [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 3,p. 1271 - 1280] Location in patent:experimental part