2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid synthesis
- Product Name:2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid
- CAS Number:1211443-58-1
- Molecular formula:C12H12ClN3O2
- Molecular Weight:265.7
1211443-55-8
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1211443-58-1
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Yield:1211443-58-1 85%
Reaction Conditions:
with oxone in N,N-dimethyl-formamide; for 6 h;
Steps:
F
A mixture of 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde (2.69 g, 11 mmol) in DMF is added oxone (7.2 g, 12 mmol) and stirred for 6 h. After the reaction is complete, water is added and a yellow solid is precipitated to give 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3- d]pyrimidine-6-carboxylic acid (2.69 g, 85%). MS(ESI) m/z 266 A (M+H)+
References:
WO2010/20675,2010,A1 Location in patent:Page/Page column 91
733039-20-8
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1211443-58-1
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1003-03-8
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1211443-58-1
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1374639-76-5
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1211443-58-1
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![(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol](/CAS/20150408/GIF/1374639-77-6.gif)
1374639-77-6
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1211443-58-1
131 suppliers
$23.00/100mg