(9S)-9-hydroxy-6,7,8,9-tetrahydrocyclohepta[b]pyridin-5-one synthesis
- Product Name:(9S)-9-hydroxy-6,7,8,9-tetrahydrocyclohepta[b]pyridin-5-one
- CAS Number:1190363-43-9
- Molecular formula:C10H11NO2
- Molecular Weight:177.2
![7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione](/CAS/GIF/39713-40-1.gif)
39713-40-1
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$155.00/50mg
![(9R)-9-hydroxy-6,7,8,9-tetrahydrocyclohepta[b]pyridin-5-one](/CAS/20180531/GIF/1190363-44-0.gif)
1190363-44-0
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1190363-43-9
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Yield:-
Reaction Conditions:
with Rh-(S-Binap)(COD)BF4;hydrogen in tetrahydrofuran at 20 - 30; under 2068.65 - 2585.81 Torr; for 48 h;Overall yield = 80.1 percent; Overall yield = 16.2 g; Optical yield = 85 percent ee;
Steps:
4 Example 4 Preparation of compound of formula III-a
20.0g (0.12mol, 1.0eq.) of cycloheptane[b]pyridine-5,9-dione, Rh- (S-Binap) (COD)BF4 0.08g (0.0009mol, 0.0075eq) and tetrahydrofuran 80mL, replace nitrogen three times, replace Hydrogen three times, pass hydrogen to pressure 40-50psi, 20-30 , react for 48 hours. 30wt% silica gel pad was filtered and concentrated to obtain the desired The target product was 16.2 g, the yield was 80.1%, and the e value was 85%.
References:
CN114805206,2022,A Location in patent:Paragraph 0132; 0168-0169
39713-40-1
137 suppliers
$155.00/50mg
1190363-43-9
15 suppliers
inquiry