5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBONITRILE synthesis

4synthesis methods

Product Name:5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
CAS Number:103646-82-8
Molecular formula:C11H10N4
Molecular Weight:198.22

123-06-8 Synthesis

123-06-8
349 suppliers
$14.14/1gm:

539-44-6
75 suppliers
inquiry

5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBONITRILE

103646-82-8
78 suppliers
$32.00/250mg

Yield: 80%

Reaction Conditions:

in ethanol for 2 h;Reflux;

Steps:

General procedure for preparing 5-amino-1-phenyl-1H-pyrazole-4-carbonitriles (10a-c)
General procedure: A mixture of the appropriate phenylhydrazine (0.001 mol)and 10 mL of ethanol was stirred and allowed to reflux.Then, 2-(ethoxymethylene)malononitrile (0.001 mol) dissolvedin 10 mL of ethanol was slowly added. The reactionmixture was refluxed for 2 h. The reaction mixture waspoured into 50 mL of ice-cold water. The precipitate wascollected by filtration and washed with water to provide10a-c in 61-80% yield.

References:

Silveira, Flávia F.;Feitosa, Lívia M.;Mafra, Jo?o C. M.;Ferreira, Maria de Lourdes G.;Rogerio, Kamilla R.;Carvalho, Leonardo J. M.;Boechat, Nubia;Pinheiro, Luiz C. S. [Medicinal Chemistry Research,2018,vol. 27,# 8,p. 1876 - 1884]

637-60-5 Synthesis