1-IODO-3,4-METHYLENEDIOXYBENZENE synthesis
- Product Name:1-IODO-3,4-METHYLENEDIOXYBENZENE
- CAS Number:5876-51-7
- Molecular formula:C7H5IO2
- Molecular Weight:248.02
274-09-9
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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5876-51-7
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Yield: 57%
Reaction Conditions:
in acetic acid
Steps:
37 3-Benzyl-1,5-epoxy-7,8methylenedioxy-1,2,4,5-tetrahydro-3-benzazepin oxalate
EXAMPLE 37 3-Benzyl-1,5-epoxy-7,8methylenedioxy-1,2,4,5-tetrahydro-3-benzazepin oxalate To a solution of 1,2-methylenedioxybenzene (24.4 g, 0.20M) in AcOH (30 ml) was added ICI (40 g, 0.250M) in AcOH (50 ml) at room temperature over 0.5 hour. The reaction mixture was stirred for an additional three hours, then poured into H2 O and extracted twice with ether. The organic extracts were washed with NaHSO3, saturated NaHCO3, H2 O, dried (MgSO4), and evaporated in vacuo. The product was distilled under vacuum at 70` C. to give 3,4-methylenedioxyiodobenzene as a pale orange liquid (28.8 g, 57% yield). NMR (CDCl3) δ 5.85 (s, 2H, O--CH2 --O), 6.50 (d, 1H, J=8 Hz, H6), 7.10 (m, 2H, J=8 Hz, J=2 Hz, H2 and H5); MS: 248 (M+).
References:
Ortho Pharmaceutical Corporation US4761413, 1988, A
274-09-9
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$5.00/5g
5876-51-7
111 suppliers
$57.00/250mg
2635-13-4
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5876-51-7
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14268-66-7
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5876-51-7
111 suppliers
$57.00/250mg
82113-65-3
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14268-66-7
265 suppliers
$20.00/5 g
5876-51-7
111 suppliers
$57.00/250mg