ChemicalBook CAS DataBase List 1-Ethoxy-3-trifluoromethyl-1,3-butadiene

1-Ethoxy-3-trifluoromethyl-1,3-butadiene synthesis

6synthesis methods

Product Name:1-Ethoxy-3-trifluoromethyl-1,3-butadiene
CAS Number:59938-06-6
Molecular formula:C6H7F3O2
Molecular Weight:168.11

109-92-2 Synthesis

109-92-2
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1-Ethoxy-3-trifluoromethyl-1,3-butadiene

59938-06-6
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$52.20/5g

Yield:59938-06-6 87%

Reaction Conditions:

with dmap;trifluoroacetic anhydride in 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

Steps:

14.A Preparation of Substituted Quinolines 88
Step A: Preparation of 4-ethoxy-trifluoro-but-3-en-2-one 84. Ethylvinylether (5 g, 1 eq.) was added dropwise at -10° C. and under nitrogen to a stirred solution of trifluoroacetic anhydride (10 mL, 1.05 eq.) and 4-dimethylaminopyridine (80 mg, 0.06 eq.) in DCM (90 mL). The reaction mixture was stirred at 0° C. for 8 hrs and allowed to warm up at room temperature overnight. The mixture was then poured into cold aqueous NaHCO₃ solution. The organic layer was separated, washed with water and brine, dried over Na₂SO₄, filtered, and concentrated under reduced pressure to yield compound 84 as brown oil in 87% yield. ¹H NMR (CDCl₃, 400 MHz) δ 1.39-1.43 (t, J=7.04 Hz, 3H), 4.08-4.13 (q, J=7.04 Hz, 2H), 5.86 (d, J=12.40 Hz, 1H), 7.90 (d, J=12.40 Hz, 1H).

References:

Idenix Pharmaceuticals, Inc. US2009/202480, 2009, A1

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109-92-2 Synthesis

109-92-2
273 suppliers
$16.00/25mL

407-25-0 Synthesis