1-cyclopropyl-2,2,2-trifluoroethan-1-ol synthesis
- Product Name:1-cyclopropyl-2,2,2-trifluoroethan-1-ol
- CAS Number:1993-77-7
- Molecular formula:C5H7F3O
- Molecular Weight:140.11
81290-20-2
410 suppliers
$13.00/1g
1489-69-6
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$6.00/1g
1993-77-7
24 suppliers
$155.00/50mg
Yield:1993-77-7 3.2 g
Reaction Conditions:
with tetrabutyl ammonium fluoride in tetrahydrofuran at 0 - 20; for 4.5 h;
Steps:
4 A16: 1 -cyclopropyl-2, 2, 2-trifluoroethan- 1 -ol
To a stirred solution of cyclopropanecarbaldehyde (5.0 g, 71.34 mmol) in THF (50.0 mL) was added trimethyl(trifluoromethyl)silane (11.16 g, 78.47 mmol) and TBAF (1.0 M in THF, 7.14 mL, 7.1 mmol) at 0 °C. The reaction mixture was slowly warmed to room temperature and stirred for 4 hours. To the reaction mixture TBAF (1.0 M in THF, 142.6 mL, 142.6 mmol) was added at room temperature and stirred for 30 min. The reaction mixture was treated with water (50.0 mL) and extracted with diethyl ether (2 x 100 mL). The organic layer was washed with 10% NaHCCb solution (50.0 mL) and brine (50 mL). The organic layer was dried over anhydrous NaiSCL and concentrated at 30 °C to afford 1- cyclopropyl-2,2,2-trifluoroethan-l-ol (3.2 g), which was used for the next step without further purification.
References:
WO2021/108513,2021,A1 Location in patent:Page/Page column 44
4333-56-6
385 suppliers
$6.00/5g
433-27-2
142 suppliers
$12.00/1g
1993-77-7
24 suppliers
$155.00/50mg
