1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE synthesis
- Product Name:1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE
- CAS Number:160809-38-1
- Molecular formula:C16H21NO4
- Molecular Weight:291.34
1126-09-6
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501-53-1
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160809-38-1
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$38.00/1g
Yield: 94%
Reaction Conditions:
with sodium carbonate in dichloromethane at 0 - 20; for 60 h;
Steps:
1 DESCRIPTION 1; Piperidine-1, 4-dicarboxylic acid 1-benzyl ester 4-ethyl ester
A solution of benzyl chloroformate (95g, 0. 56mol) in dichloromethane (200ml) was added dropwise to an ice-bath-cooled, stirred mixture of ethyl isonipecotate (87G, 0. 55MOL), sodium carbonate (60g, 0. 57mol) and dichloromethane (200ml) over 70 minutes. The mixture was stirred at ambient temperature for 2.5 days and filtered though a pad of Celte. The filtrate was concentrated in vacuo. The residue was partitioned between 2M aqueous hydrochloric acid and diethyl ether. Organic layer was separated, dried (MGS04), filtered and concentrated. The residue was chromatographed on silica gel (ethyl ACETATE/ISO-HEXANE) to give the title product (152g, 94%). lE NMR (360 MHz, CDCl3) : 5 7. 4 1-7. 27 (5H, M), 5.12 (2EI, s), 4.22-3. 99 (2H, M), 4. 14 (2H, Q, J7. 4HZ), 2.93 (2H, br T, J 11. 6HZ), 2.45 (2H, m), 1.97-1. 81 (2H, M), 1.74-1. 56 (2EI, m), 1. 25 (3H, T, J7. 4Hz).
References:
MERCK SHARP & DOHME LIMITED WO2004/78750, 2004, A1 Location in patent:Page 64
![1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid](/CAS/GIF/10314-98-4.gif)
10314-98-4
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$6.00/1g
75-03-6
364 suppliers
$11.00/5g
160809-38-1
95 suppliers
$38.00/1g
1126-09-6
489 suppliers
$15.40/25g
13139-17-8
519 suppliers
$6.00/25g
160809-38-1
95 suppliers
$38.00/1g