ChemicalBook CAS DataBase List 1-BENZYL-3-METHYL-4-PIPERIDONE

1-BENZYL-3-METHYL-4-PIPERIDONE synthesis

8synthesis methods

Product Name:1-BENZYL-3-METHYL-4-PIPERIDONE
CAS Number:34737-89-8
Molecular formula:C13H17NO
Molecular Weight:203.28

7006-50-0
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$18.00/1g

7087-68-5 Synthesis

7087-68-5
572 suppliers
$9.00/1g

34737-89-8
10 suppliers
$9.00/1g

Yield:34737-89-8 71%

Reaction Conditions:

in dichloromethane

Steps:

7.3 Preparation of (+,-)-1,1-dimethylethyl-4-[[2-[2-(3,4-dichlorophenyl)-1-(3,5-dimethylbenzoyl)-1-piperazinyl]-2-oxoethyl]amino]-1-piperidinecarboxylate STR84
201.3. To a solution of bromoacetyl derivative 3 (3.0 g,6.2 mmol) (prepared in Example 3) in CH₂ Cl₂ (62 mL) at -10° C. were added Hunig's base (1.2 mL, 6.82 mmol) and compound 2 (2.48 g, 12.39 mmol). The solution was gradually warmed to RT overnight. After reaction was complete, CH₂ Cl₂ (300 mL) was added and washed with brine (100 mL, 3*), dried over MgSO₄ and filtered. The filtrate was evaporated to dryness to give a light yellow solid which was purified by flash chromatography on flash grade silica gel (200 g), eluding with 5% ?NH₄ OH/MeOH[(1:9)]/CH₂ Cl₂ to give 71% yield of the title compound 4 as a white solid (2.66 g, 4.4 mmol), m.p. 78°-81° C.; FAB MS [M+1]⁺ 35 Cl 603.1; Calcd. for C₃₁ H₄₀ N₄ O₄ Cl₂, C, 61.69; H, 6.68; N,9.28; Cl, 11.74. Found: C, 61.33; H, 6.94; N, 9.17; Cl, 11.27.