成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

38936-62-8

1-[(AMINOOXY)METHYL]-4-METHYLBENZENE HYDROCHLORIDE synthesis

5synthesis methods
-

Yield:38936-62-8 69%

Reaction Conditions:

Stage #1: 2-((4-methylbenzyl)oxy)isoindoline-1,3-dionewith hydrazine hydrate monohydrate in tetrahydrofuran at 20; for 1 h;
Stage #2: with hydrogenchloride in 1,4-dioxane at 20; for 0.5 h;

Steps:

2.2 Step 2: O-(4-methylbenzyl)hydroxylamine hydrochloride (XIVb)

To a stirred solution of 48 XIIIb (2.0 g, 7.49 mmol) in 32 THF (20 mL) was added 80% 33 hydrazine hydrate (700 mg, 14.98 mmol) at room temperature and stirred for 1 h. The reaction mixture was filtered, and the filtrate was evaporated under vacuum to give crude 50 XIVb (1 g). The crude product was dissolved in 1,4-dioxane (10 mL), 4N HCl in dioxane (10 mL) was added, and the system was stirred for 30 min at room temperature. The reaction mixture was concentrated and triturated with pentane (10 mL) and diethyl ether (10 mL) to give XIVb (900 mg, 69% yield) as a white solid. LCMS: m/z: 138 [M+H]+ observed, RT=1.78 min (Method B).

References:

US2019/169128,2019,A1 Location in patent:Paragraph 0217; 0219