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ChemicalBook CAS DataBase List 1-(4-Trifluoromethylphenyl)piperidin-4-ol
681508-70-3

1-(4-Trifluoromethylphenyl)piperidin-4-ol synthesis

2synthesis methods
-

Yield:681508-70-3 85.6%

Reaction Conditions:

with 1,4-diaza-bicyclo[2.2.2]octane;nickel(II) bromide dimethoxyethane;zinc in N,N-dimethyl acetamide at 20; for 18 h;Inert atmosphere;Glovebox;Sealed tube;

References:

Nocera, Daniel G.;Qin, Yangzhong;Sun, Rui [Angewandte Chemie - International Edition,2020,vol. 59,# 24,p. 9527 - 9533][Angew. Chem.] Location in patent:supporting information

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