ChemicalBook CAS DataBase List 1-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIOUREA

1-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIOUREA synthesis

9synthesis methods

Product Name:1-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIOUREA
CAS Number:1736-72-7
Molecular formula:C8H7F3N2S
Molecular Weight:220.21

455-14-1
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$5.00/10g

333-20-0
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$13.50/100G

1-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIOUREA

1736-72-7
85 suppliers
$34.00/1g

Yield: 100%

Reaction Conditions:

with hydrogenchloride in waterHeating / reflux;

Steps:

440.C
4-Trifluoromethylaniline (2.00 g; 12.4 mmol) and potassium thiocyanate (4.82 g; 49.7 mmol) was suspended in 1 N aqueous HCI (20 ml). A clear solution was obtained upon heating to reflux (after 1 hour, a precipitate started to form). The mixture was refluxed overnight, then cooled to room temperature and extracted with ethyl acetate. The organic phase was washed with brine and dried with anhydrous sodium sulphate. Solvent was removed, and the residual oil was striped twice from acetonitril, to give a quantitative yield of (4- trifluoromethylphenyl) thiourea. 1H-NMR(DMSO-d6, selected peaks): 8 7.15 ppm (d, 2H); 7.25 (d, 2H); 10.2 (s, 1H). HPLC-MS (Method B): m/z: 221 (M+1), Rt: 2.69 min.

References:

NOVO NORDISK A/S WO2004/2480, 2004, A1 Location in patent:Page/Page column 150