1-(4-Chlorobut-1-yn-1-yl)-4-fluorobenzene synthesis
1synthesis methods
- Product Name:1-(4-Chlorobut-1-yn-1-yl)-4-fluorobenzene
- CAS Number:1183278-95-6
- Molecular formula:C10H8ClF
- Molecular Weight:182.62
Yield:1183278-95-6 75%
Reaction Conditions:
with bis-triphenylphosphine-palladium(II) chloride;copper(l) iodide;triethylamine in 1,4-dioxane at 50; for 3 h;Sonogashira Cross-Coupling;
References:
Fyfe, Tim J.;Kellam, Barrie;Sykes, David A.;Capuano, Ben;Scammells, Peter J.;Lane, J. Robert;Charlton, Steven J.;Mistry, Shailesh N. [Journal of Medicinal Chemistry,2019,vol. 62,# 21,p. 9488 - 9520]