1-(4-Bromophenyl)-4-propoxybenzene synthesis
- Product Name:1-(4-Bromophenyl)-4-propoxybenzene
- CAS Number:154020-02-7
- Molecular formula:C15H15BrO
- Molecular Weight:291.18
29558-77-8
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$6.00/5g
106-94-5
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$10.00/5ml
154020-02-7
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$55.00/250mg
Yield:154020-02-7 97.8%
Reaction Conditions:
with potassium carbonate in butanone; for 8 h;Reflux;
Steps:
General procedure: A suspension of 4-bromo-4'-hydroxybiphenyl (13) (3.5 g, 14.11 mmol), 1-bromoheptane (3.75 g, 21.05 mmol) and K2CO3 (4.9 g, 35.28 mmol) in 2-butanone (25 mL) was refluxed for 8 h. After cooling, the reaction mixture was diluted by CH2Cl2 (50 mL). After filtration, the organic layer was washed by H2O (50 mL) and saturated brine (50 mL), dried over anhydrous Na2SO4, and filtrated. The solvent was condensed to 15 mL under reduced pressure, and the residue was collected and washed by cool hexane (0 °C) to afford 14c (4.6 g, yield 94.3%) as white solid.
References:
Yao, Jianzhong;Liu, Hongming;Zhou, Ting;Chen, Hai;Miao, Zhenyuan;Sheng, Chunquan;Zhang, Wannian [European Journal of Medicinal Chemistry,2012,vol. 50,p. 196 - 208] Location in patent:supporting information; experimental part
148-86-7
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$11.00/5g
154020-02-7
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$55.00/250mg
92-69-3
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$6.00/25g
154020-02-7
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$55.00/250mg
84244-98-4
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$45.00/250mg
154020-02-7
20 suppliers
$55.00/250mg