1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE synthesis
- Product Name:1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE
- CAS Number:4101-32-0
- Molecular formula:C10H11NO5
- Molecular Weight:225.2
1131-62-0
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4101-32-0
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Yield: 89.4%
Reaction Conditions:
with nitric acid in dichloromethane at -10; for 2 h;
Steps:
1.2. General procedure for preparation of(1)
A mixture of 3,4-dimethoxyacetophenone (100.0 g, 0.6 mol) in CH2Cl2(500 mL, 5 v/w) was stirred at -10oC.98% HNO3(70 mL) was added slowly dropwise and then was stirred for 2 h. The reaction solution was poured into ice water with vigorous stirring, and the aqueous phase was extracted with dichloromethane, washed with water, dried over Na2SO4and then concentrated under reduced pressure to give compound1as a yellow solid in 89.4% yield.
References:
Xu, Qiaoling;Dai, Baozhu;Li, Zhiwei;Xu, Le;Yang, Di;Gong, Ping;Hou, Yunlei;Liu, Yajing [Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,# 19,art. no. 126630] Location in patent:supporting information
498-02-2
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4101-32-0
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91-16-7
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4101-32-0
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7664-93-9
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7697-37-2
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1131-62-0
323 suppliers
$14.00/5g
4101-32-0
111 suppliers
$22.39/1G
7697-37-2
8 suppliers
$13.00/25g
1131-62-0
323 suppliers
$14.00/5g
4101-32-0
111 suppliers
$22.39/1G