1-(2-phenylethyl)-1H-pyrazol-4-amine synthesis
- Product Name:1-(2-phenylethyl)-1H-pyrazol-4-amine
- CAS Number:28466-65-1
- Molecular formula:C11H13N3
- Molecular Weight:187.24
28469-23-0
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28466-65-1
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Yield:28466-65-1 94%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol; for 4 h;
Steps:
1786.1786B 1786B: 1-phenethyl-1H-pyrazol-4-amine
To 10% Pd-C (80 mg, 0.075 mmol) was added a solution of 4-nitro-1-phenethyl-1H-pyrazole (215 mg, 0.990 mmol) in MeOH (5 mL) under N2. The mixture was stirred under H2 balloon for 4 h. Pd/C was filtered out. The filtrate was concentrated to give 1-phenethyl-1H-pyrazol-4-amine (175 mg, 0.935 mmol, 94 % yield). (2396) MS ESI m/z 188.1 (M+H)+ (2397) 1H NMR (499 MHz, CDCl3) δ 7.33 - 7.22 (m, 3H), 7.20 (d, J=0.7 Hz, 1H), 7.14 (d, J=7.1 Hz, 2H), 6.86 (d, J=0.8 Hz, 1H), 4.27 - 4.20 (m, 2H), 3.14 (t, J=7.5 Hz, 2H).
References:
WO2019/147782,2019,A1 Location in patent:Page/Page column 758; 759
103-63-9
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28466-65-1
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38661-81-3
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