Yield:56471-90-0 93%

Reaction Conditions:

with ammonium formate;palladium 10% on activated carbon in ethanol at 60; for 1 h;sealed tube;

Steps:

12

A mixture of 4-isopropyl-2-nitroaniline (445 mg, 2.47 mmol), Pd/C (132 mg, 10%, 0.123 mmol), ammonium formate (623 mg, 9.88 mmol) and EtOH (6 ml) in a sealed tube was stirred for 1 h at 60 °C. After cooling down, EtOAc (5 ml) was added and the resulting mixture was filtered through celite. The organic filtrate was concentrated and dissolved in EtOAc (5 ml). The mixture was filtered through celite again. Concentration of the organic filtrate gave isopropylbenzene-l,2-diamine (345 mg, 93%) as a brown oil. MS (EI) for C₉H₁₄N₂: 151.2 (MH⁺).

References:

WO2012/61337,2012,A1 Location in patent:Page/Page column 61