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ChemicalBook >> CAS DataBase List >> VcMMAE

VcMMAE

VcMMAE price.
  • $145 - $6247.5
  • Product name: VcMMAE
  • CAS: 646502-53-6
  • MF: C68H105N11O15
  • MW: 1316.63
  • EINECS:
  • MDL Number:MFCD25372036
  • Synonyms:VcMMAE;Maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl-monomethyl auristatin E;4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-y;MC-VC-PAB-MMAE,MC-Val-Cit-PAB-MMAE;maleimido-caproyl-val-Cit-PAB-MMAE;VeMMAE;EOS-60990;4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-Uriedidopenamiamido)benzyl((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S),2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-y
18 prices
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Brand
  • Ambeed
  • Biorbyt Ltd
  • BroadPharm
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAmbeed
  • Product numberA153774
  • Product descriptionVcMMAE 98+%
  • Packaging1mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153774
  • Product descriptionVcMMAE 98+%
  • Packaging5mg
  • Price$570
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA153774
  • Product descriptionVcMMAE 98+%
  • Packaging10mg
  • Price$955
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153774
  • Product descriptionVcMMAE 98+%
  • Packaging25mg
  • Price$1760
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573074
  • Product descriptionVcMMAE >99.11%
  • Packaging100mg
  • Price$1949.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573074
  • Product descriptionVcMMAE >99.11%
  • Packaging250mg
  • Price$3282.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573074
  • Product descriptionVcMMAE >99.11%
  • Packaging1g
  • Price$6247.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-23969
  • Product descriptionMC-Val-Cit-PAB-MMAE 98%
  • Packaging1mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-23969
  • Product descriptionMC-Val-Cit-PAB-MMAE 98%
  • Packaging5mg
  • Price$265
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-23969
  • Product descriptionMC-Val-Cit-PAB-MMAE 98%
  • Packaging10mg
  • Price$410
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM328218
  • Product description[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methylN-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-o 95%+
  • Packaging1g
  • Price$1104
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-1242
  • Product descriptionVcMMAE 99.89%
  • Packaging250mg
  • Price$1580
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-1242
  • Product descriptionVcMMAE 99.89%
  • Packaging1g
  • Price$3950
  • Updated2021-12-16
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  • ManufacturerCrysdot
  • Product numberCD35000045
  • Product descriptionVcMMAE 98+%
  • Packaging50mg
  • Price$3748
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD35000045
  • Product descriptionVcMMAE 98+%
  • Packaging10mg
  • Price$1250
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD35000045
  • Product descriptionVcMMAE 98+%
  • Packaging5mg
  • Price$830
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A153774 VcMMAE 98+% 1mg $210 2021-12-16 Buy
Ambeed A153774 VcMMAE 98+% 5mg $570 2021-12-16 Buy
Ambeed A153774 VcMMAE 98+% 10mg $955 2021-12-16 Buy
Ambeed A153774 VcMMAE 98+% 25mg $1760 2021-12-16 Buy
Biorbyt Ltd orb573074 VcMMAE >99.11% 100mg $1949.9 2021-12-16 Buy
Biorbyt Ltd orb573074 VcMMAE >99.11% 250mg $3282.7 2021-12-16 Buy
Biorbyt Ltd orb573074 VcMMAE >99.11% 1g $6247.5 2021-12-16 Buy
BroadPharm BP-23969 MC-Val-Cit-PAB-MMAE 98% 1mg $145 2021-12-16 Buy
BroadPharm BP-23969 MC-Val-Cit-PAB-MMAE 98% 5mg $265 2021-12-16 Buy
BroadPharm BP-23969 MC-Val-Cit-PAB-MMAE 98% 10mg $410 2021-12-16 Buy
Chemenu CM328218 [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methylN-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-o 95%+ 1g $1104 2021-12-16 Buy
ChemScene CS-1242 VcMMAE 99.89% 250mg $1580 2021-12-16 Buy
ChemScene CS-1242 VcMMAE 99.89% 1g $3950 2021-12-16 Buy
Crysdot CD35000045 VcMMAE 98+% 50mg $3748 2021-12-16 Buy
Crysdot CD35000045 VcMMAE 98+% 10mg $1250 2021-12-16 Buy
Crysdot CD35000045 VcMMAE 98+% 5mg $830 2021-12-16 Buy

Properties

Boiling point :1347.6±65.0 °C(Predicted)
Density :1.196±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO, DCM, DMF
form :A solid
pka :13.29±0.70(Predicted)
color :White to off-white
InChIKey :NLMBVBUNULOTNS-NNNQBTKHNA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. VcMMAE can be used to make antibody drug conjugate. VcMMAE is a anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer?