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ChemicalBook >> CAS DataBase List >> Tadalafil

Tadalafil

Tadalafil price.
  • $10 - $1095
  • Product name: Tadalafil
  • CAS: 171596-29-5
  • MF: C22H19N3O4
  • MW: 389.4
  • EINECS:687-782-2
  • MDL Number:MFCD07771966
  • Synonyms:ICOS 351;UK 336017;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;Cialis ,98%;Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)-
33 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemcia Scientific
  • ChemScene
  • Chemtos
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 20mg
  • 50mg
  • y0001417
  • 25mg
  • 10
  • 10mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1mL
  • 10mM(in 1mL DMSO)
  • 1g
  • 25g
  • 50g
  • 100g
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-T0455-M050
  • Product descriptionTadalafil ≥98%
  • Packaging50mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95138
  • Product descriptionTadalafil
  • Packaging1g
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberA531
  • Product descriptionTadalafil
  • Packaging25mg
  • Price$48
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberA531
  • Product descriptionTadalafil
  • Packaging250mg
  • Price$230
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4327
  • Product descriptionTadalafil
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4327
  • Product descriptionTadalafil
  • Packaging50mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4327
  • Product descriptionTadalafil
  • Packaging100mg
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4327
  • Product descriptionTadalafil
  • Packaging500mg
  • Price$469
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60416
  • Product descriptionTadalafil ≥98%
  • Packaging20mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBT164435
  • Product descriptionTadalafil
  • Packaging25mg
  • Price$38
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBT164435
  • Product descriptionTadalafil
  • Packaging100mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14024
  • Product descriptionTadalafil ≥98%
  • Packaging10mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14024
  • Product descriptionTadalafil ≥98%
  • Packaging25mg
  • Price$61
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14024
  • Product descriptionTadalafil ≥98%
  • Packaging50mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14024
  • Product descriptionTadalafil ≥98%
  • Packaging100mg
  • Price$172
  • Updated2024-03-01
  • Buy
  • ManufacturerChemcia Scientific
  • Product numberCC00-7612
  • Product descriptionTadalafil >97%
  • Packaging50g
  • Price$125
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-T0455-M050 Tadalafil ≥98% 50mg $65 2021-12-16 Buy
AK Scientific J95138 Tadalafil 1g $10 2021-12-16 Buy
AK Scientific A531 Tadalafil 25mg $48 2021-12-16 Buy
AK Scientific A531 Tadalafil 250mg $230 2021-12-16 Buy
ApexBio Technology A4327 Tadalafil 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A4327 Tadalafil 50mg $77 2021-12-16 Buy
ApexBio Technology A4327 Tadalafil 100mg $119 2021-12-16 Buy
ApexBio Technology A4327 Tadalafil 500mg $469 2021-12-16 Buy
Arctom CFN60416 Tadalafil ≥98% 20mg $30 2021-12-16 Buy
Biosynth Carbosynth BT164435 Tadalafil 25mg $38 2021-12-16 Buy
Biosynth Carbosynth BT164435 Tadalafil 100mg $130 2021-12-16 Buy
Cayman Chemical 14024 Tadalafil ≥98% 10mg $44 2024-03-01 Buy
Cayman Chemical 14024 Tadalafil ≥98% 25mg $61 2024-03-01 Buy
Cayman Chemical 14024 Tadalafil ≥98% 50mg $109 2024-03-01 Buy
Cayman Chemical 14024 Tadalafil ≥98% 100mg $172 2024-03-01 Buy
Chemcia Scientific CC00-7612 Tadalafil >97% 50g $125 2021-12-16 Buy

Properties

Melting point :298-300°C
alpha :D20 +71.0°
Boiling point :679.1±55.0 °C(Predicted)
Density :1.51±0.1 g/cm3(Predicted)
Flash point :2℃
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :16.68±0.40(Predicted)
color :white to beige
optical activity :[α]/D +68 to +78°, c = 1 in chloroform-d
BCS Class :4
Stability :Unstable in Methanol
InChI :InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
InChIKey :WOXKDUGGOYFFRN-IIBYNOLFSA-N
SMILES :N1C2=C(C=CC=C2)C2C[C@]3([H])C(=O)N(C)CC(=O)N3[C@H](C3=CC=C4OCOC4=C3)C1=2
CAS DataBase Reference :171596-29-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.

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