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ChemicalBook >> CAS DataBase List >> Sivelestat sodium

Sivelestat sodium

Sivelestat sodium price.
  • $45 - $3698
  • Product name: Sivelestat sodium
  • CAS: 201677-61-4
  • MF: C20H25N2NaO8S
  • MW: 476.48
  • EINECS:
  • MDL Number:MFCD01937969
  • Synonyms:SIVELESTAT SODIUM HYDRATE;SIVELESTAT SODIUM TETRAHYDRATE;n-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(s)-glycine monosodium salt tetrahydrate;Sivelestat sodium;N-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-Glycine monosodium salt tetrahydrate;Sivelestat(anhydrous);Glycine, N-[2-[[[4-(2,2-diMethyl-1-oxopropoxy)phenyl]sulfonyl]aMino]benzoyl]-, MonosodiuM salt, tetrahydrate;sodium,2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate,tetrahydrate
29 prices
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Arctom
  • Ark Pharm
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberJ98651
  • Product descriptionSivelestatsodiumtetrahydrate
  • Packaging50mg
  • Price$249
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA274870
  • Product descriptionSivelestatsodiumtetrahydrate 98+%
  • Packaging5mg
  • Price$51
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA274870
  • Product descriptionSivelestatsodiumtetrahydrate 98+%
  • Packaging10mg
  • Price$86
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA274870
  • Product descriptionSivelestatsodiumtetrahydrate 98+%
  • Packaging50mg
  • Price$287
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA274870
  • Product descriptionSivelestatsodiumtetrahydrate 98+%
  • Packaging100mg
  • Price$435
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA274870
  • Product descriptionSivelestatsodiumtetrahydrate 98+%
  • Packaging1g
  • Price$3698
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008936
  • Product descriptionSIVELESTAT SODIUM HYDRATE 97.00%
  • Packaging5MG
  • Price$217.8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008936
  • Product descriptionSIVELESTAT SODIUM HYDRATE 97.00%
  • Packaging1G
  • Price$2073.23
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS503289
  • Product descriptionSivelestatsodiumtetrahydrate ≥98%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS503289
  • Product descriptionSivelestatsodiumtetrahydrate ≥98%
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS503289
  • Product descriptionSivelestatsodiumtetrahydrate ≥98%
  • Packaging50mg
  • Price$284
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS503289
  • Product descriptionSivelestatsodiumtetrahydrate ≥98%
  • Packaging100mg
  • Price$431
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberAK546607
  • Product descriptionSivelestatsodiumtetrahydrate 98+%
  • Packaging50mg
  • Price$349
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17779
  • Product descriptionSivelestat (sodium salt hydrate) ≥98%
  • Packaging5mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17779
  • Product descriptionSivelestat (sodium salt hydrate) ≥98%
  • Packaging10mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17779
  • Product descriptionSivelestat (sodium salt hydrate) ≥98%
  • Packaging25mg
  • Price$254
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J98651 Sivelestatsodiumtetrahydrate 50mg $249 2021-12-16 Buy
Ambeed A274870 Sivelestatsodiumtetrahydrate 98+% 5mg $51 2021-12-16 Buy
Ambeed A274870 Sivelestatsodiumtetrahydrate 98+% 10mg $86 2021-12-16 Buy
Ambeed A274870 Sivelestatsodiumtetrahydrate 98+% 50mg $287 2021-12-16 Buy
Ambeed A274870 Sivelestatsodiumtetrahydrate 98+% 100mg $435 2021-12-16 Buy
Ambeed A274870 Sivelestatsodiumtetrahydrate 98+% 1g $3698 2021-12-16 Buy
American Custom Chemicals Corporation API0008936 SIVELESTAT SODIUM HYDRATE 97.00% 5MG $217.8 2021-12-16 Buy
American Custom Chemicals Corporation API0008936 SIVELESTAT SODIUM HYDRATE 97.00% 1G $2073.23 2021-12-16 Buy
Arctom AS503289 Sivelestatsodiumtetrahydrate ≥98% 5mg $50 2021-12-16 Buy
Arctom AS503289 Sivelestatsodiumtetrahydrate ≥98% 10mg $85 2021-12-16 Buy
Arctom AS503289 Sivelestatsodiumtetrahydrate ≥98% 50mg $284 2021-12-16 Buy
Arctom AS503289 Sivelestatsodiumtetrahydrate ≥98% 100mg $431 2021-12-16 Buy
Ark Pharm AK546607 Sivelestatsodiumtetrahydrate 98+% 50mg $349 2021-12-16 Buy
Cayman Chemical 17779 Sivelestat (sodium salt hydrate) ≥98% 5mg $62 2024-03-01 Buy
Cayman Chemical 17779 Sivelestat (sodium salt hydrate) ≥98% 10mg $109 2024-03-01 Buy
Cayman Chemical 17779 Sivelestat (sodium salt hydrate) ≥98% 25mg $254 2024-03-01 Buy

Properties

storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 20 mg/ml).
form :White solid.
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
CAS DataBase Reference :201677-61-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase (HNE) (IC50 = 44 nM, Ki = 0.2 M). Sivelestat sodium tetrahydrate also effectively inhibits leukocyte elastase derived from hamster, mouse, rabbit and rat (IC50 = 19 to 49 nM). Sivelestat sodium tetrahydrate, even at concentrations of 100 M, does not inhibit plasma kallikrein, plasmin, thrombin, trypsin, pancreas kallikrein, chymotrypsin and cathepsin G. In in-vivo studies, sivelestat sodium tetrahydrate suppressed lung hemorrhage in hamster (ID50 = 82 g/kg) by intratracheal administration and increased skin capillary permeability in guinea pigs (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase.

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