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ChemicalBook >> CAS DataBase List >> SU 11274

SU 11274

SU 11274 price.
  • $44 - $2501.5
  • Product name: SU 11274
  • CAS: 658084-23-2
  • MF: C28H30ClN5O4S
  • MW: 568.09
  • EINECS:
  • MDL Number:MFCD08276928
  • Synonyms:PKI-SU11274;N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide;N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide SU11274;SU 11274, >=98%;Met Kinase Inhibitor;(Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)methy;(3z)-n-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1h-pyrrol-2-yl}methylene)-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide;SU 11274，SU 11274
20 prices
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Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 500μg
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100MG
  • 250mg
  • 1g
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004248
  • Product descriptionSU 11274 95.00%
  • Packaging5MG
  • Price$348.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004248
  • Product descriptionSU 11274 95.00%
  • Packaging100MG
  • Price$2501.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2678
  • Product descriptionSU 11274
  • Packaging100mg
  • Price$715
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60187
  • Product descriptionSU 11274
  • Packaging10mg
  • Price$268
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154635
  • Product descriptionSU11274 (PKI-SU11274) >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154635
  • Product descriptionSU11274 (PKI-SU11274) >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154635
  • Product descriptionSU11274 (PKI-SU11274) >98%
  • Packaging1g
  • Price$2395.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS65178
  • Product descriptionSU 11274
  • Packaging10mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS65178
  • Product descriptionSU 11274
  • Packaging50mg
  • Price$507.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14861
  • Product descriptionSU 11274 ≥95%
  • Packaging500μg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14861
  • Product descriptionSU 11274 ≥95%
  • Packaging1mg
  • Price$84
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14861
  • Product descriptionSU 11274 ≥95%
  • Packaging5mg
  • Price$130
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0144
  • Product descriptionSU 11274 98.19%
  • Packaging10mg
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0144
  • Product descriptionSU 11274 98.19%
  • Packaging50mg
  • Price$677
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0144
  • Product descriptionSU 11274 98.19%
  • Packaging100mg
  • Price$858
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC1093
  • Product descriptionSU11274(PKI-SU11274) >98%
  • Packaging250mg
  • Price$800
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation API0004248 SU 11274 95.00% 5MG $348.6 2021-12-16 Buy
American Custom Chemicals Corporation API0004248 SU 11274 95.00% 100MG $2501.5 2021-12-16 Buy
ApexBio Technology A2678 SU 11274 100mg $715 2021-12-16 Buy
Arctom CFN60187 SU 11274 10mg $268 2021-12-16 Buy
Biorbyt Ltd orb154635 SU11274 (PKI-SU11274) >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb154635 SU11274 (PKI-SU11274) >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb154635 SU11274 (PKI-SU11274) >98% 1g $2395.3 2021-12-16 Buy
Biosynth Carbosynth FS65178 SU 11274 10mg $145 2021-12-16 Buy
Biosynth Carbosynth FS65178 SU 11274 50mg $507.5 2021-12-16 Buy
Cayman Chemical 14861 SU 11274 ≥95% 500μg $44 2024-03-01 Buy
Cayman Chemical 14861 SU 11274 ≥95% 1mg $84 2024-03-01 Buy
Cayman Chemical 14861 SU 11274 ≥95% 5mg $130 2024-03-01 Buy
ChemScene CS-0144 SU 11274 98.19% 10mg $185 2021-12-16 Buy
ChemScene CS-0144 SU 11274 98.19% 50mg $677 2021-12-16 Buy
ChemScene CS-0144 SU 11274 98.19% 100mg $858 2021-12-16 Buy
DC Chemicals DC1093 SU11274(PKI-SU11274) >98% 250mg $800 2021-12-16 Buy

Properties

Density :1.401±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 10 mg/mL at 60 °C
pka :11.62±0.20(Predicted)
form :powder
color :orange
InChIKey :FPYJSJDOHRDAMT-KQWNVCNZSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in a many types of cancer. SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM). It has much less or no activity against other receptor tyrosine kinases. SU11274 induces apoptosis and cell cycle arrest in transformed BaF3 cells and cancer cell lines.

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