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ChemicalBook >> CAS DataBase List >> SGI-1776

SGI-1776

SGI-1776 price.
  • $28 - $3136.5
  • Product name: SGI-1776
  • CAS: 1025065-69-3
  • MF: C20H22F3N5O
  • MW: 405.42
  • EINECS:200-258-5
  • MDL Number:MFCD16659064
  • Synonyms:N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine;N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine SGI-1776;SGI-1776;SGI-1776 free base;N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine;SGI-1776, >=98%;SGI-1776 free base N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine;SGI-1776 FREE BASE;SGI1776
28 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 10mg
  • 25mg
  • 50mg
  • 250mg
  • 1000mg
  • 1unit
  • 1mg
  • 10mM(in 1mL DMSO)
  • 5mg
  • 100mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1193-M001
  • Product descriptionSGI-1776 ≥95%
  • Packaging1mg
  • Price$86
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1193-M100
  • Product descriptionSGI-1776 ≥95%
  • Packaging100mg
  • Price$1188
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1193
  • Product descriptionSGI-1776
  • Packaging100mg
  • Price$1120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4192
  • Product descriptionSGI-1776freebase
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4192
  • Product descriptionSGI-1776freebase
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4192
  • Product descriptionSGI-1776freebase
  • Packaging10mM(in 1mL DMSO)
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4192
  • Product descriptionSGI-1776freebase
  • Packaging10mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4192
  • Product descriptionSGI-1776freebase
  • Packaging50mg
  • Price$410
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60248
  • Product descriptionSGI-1776freebase ≥98%
  • Packaging10mg
  • Price$358
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1633
  • Product descriptionSGI1776freebase 98%
  • Packaging25mg
  • Price$357.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181025
  • Product descriptionSGI-1776 >98%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181025
  • Product descriptionSGI-1776 >98%
  • Packaging250mg
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181025
  • Product descriptionSGI-1776 >98%
  • Packaging1000mg
  • Price$3136.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16423
  • Product descriptionSGI-1776 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16423
  • Product descriptionSGI-1776 ≥98%
  • Packaging5mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16423
  • Product descriptionSGI-1776 ≥98%
  • Packaging10mg
  • Price$214
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1193-M001 SGI-1776 ≥95% 1mg $86 2021-12-16 Buy
Adipogen Life Sciences SYN-1193-M100 SGI-1776 ≥95% 100mg $1188 2021-12-16 Buy
AK Scientific SYN1193 SGI-1776 100mg $1120 2021-12-16 Buy
ApexBio Technology A4192 SGI-1776freebase 1unit $28 2021-12-16 Buy
ApexBio Technology A4192 SGI-1776freebase 5mg $90 2021-12-16 Buy
ApexBio Technology A4192 SGI-1776freebase 10mM(in 1mL DMSO) $100 2021-12-16 Buy
ApexBio Technology A4192 SGI-1776freebase 10mg $170 2021-12-16 Buy
ApexBio Technology A4192 SGI-1776freebase 50mg $410 2021-12-16 Buy
Arctom CFN60248 SGI-1776freebase ≥98% 10mg $358 2021-12-16 Buy
Axon Medchem Axon1633 SGI1776freebase 98% 25mg $357.5 2021-12-16 Buy
Biorbyt Ltd orb181025 SGI-1776 >98% 100mg $838.1 2021-12-16 Buy
Biorbyt Ltd orb181025 SGI-1776 >98% 250mg $1504.5 2021-12-16 Buy
Biorbyt Ltd orb181025 SGI-1776 >98% 1000mg $3136.5 2021-12-16 Buy
Cayman Chemical 16423 SGI-1776 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 16423 SGI-1776 ≥98% 5mg $139 2024-03-01 Buy
Cayman Chemical 16423 SGI-1776 ≥98% 10mg $214 2024-03-01 Buy

Properties

Density :1.37
storage temp. :Store at -20°C
solubility :≥40.5 mg/mL in DMSO; insoluble in H2O; ≥101 mg/mL in EtOH
pka :9.22±0.10(Predicted)
form :Solid
color :White to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

The Pim family proteins are serine/threonine kinases involved in cancer progression. SGI-1776 is a potent inhibitor of all three human Pim kinases (IC50s = 7, 363, and 69 nM for Pim-1, Pim-2, and Pim-3, respectively). While it also inhibits FLT3 and haspin (IC50s = 44 and 34 nM, respectively), SGI-1776 has little effect on several other kinases, including cell cycle kinases. SGI-1776 induces apoptosis in lymphocytes from patients with chronic or acute lymphocytic leukemia but not in those from healthy donors. At 10 μM, it reduces STAT3 phosphorylation without reducing STAT3 expression in cancer cells, and this correlates with inhibition of cell proliferation. SGI-1776 also enhances the activity of sunitinib against renal cell carcinoma and resensitizes chemoresistant prostate cancer cells to taxanes.

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