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ChemicalBook >> CAS DataBase List >> Parthenolide

Parthenolide

Parthenolide price.
  • $28 - $800
  • Product name: Parthenolide
  • CAS: 20554-84-1
  • MF: C15H20O3
  • MW: 248.32
  • EINECS:692-532-0
  • MDL Number:MFCD00134592
  • Synonyms:[1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one;(1aR,4E,7aS,10aS,10bS)-2,3,6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one;4,5α-Epoxy-6β-hydroxygermacra-1(10),11(13)-dien-12-oic acid γ-lactone;4,5alpha-epoxy-6beta-hydroxy-germacra-1(10),11(13)-dien-12-oic acid gamma-lactone;Germacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactone;Parthenolide;Parthenolide ((-)-Parthenolide);PartheNAlide
52 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • JR MediChem
  • Labseeker
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
Package
  • 10mM(in 1mL DMSO)
  • 1unit
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100MG
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 2g
  • 5g
  • 10g
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-P0297-M025
  • Product descriptionParthenolide ≥98%(HPLC)
  • Packaging25mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberV0355
  • Product descriptionParthenolide
  • Packaging200mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000298
  • Product descriptionPARTHENOLIDE 95.00%
  • Packaging25MG
  • Price$150.15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000298
  • Product descriptionPARTHENOLIDE 95.00%
  • Packaging100MG
  • Price$642.99
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1315
  • Product descriptionParthenolide
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1315
  • Product descriptionParthenolide
  • Packaging50mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1315
  • Product descriptionParthenolide
  • Packaging100mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1315
  • Product descriptionParthenolide
  • Packaging10mM(in 1mL DMSO)
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1315
  • Product descriptionParthenolide
  • Packaging250mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIP0110
  • Product descriptionParthenolide
  • Packaging50mg
  • Price$73
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIP0110
  • Product descriptionParthenolide
  • Packaging100mg
  • Price$116
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIP0110
  • Product descriptionParthenolide
  • Packaging250mg
  • Price$254
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020015
  • Product description(-)-Parthenolide 97%
  • Packaging50mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020015
  • Product description(-)-Parthenolide 97%
  • Packaging100mg
  • Price$38
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN98034
  • Product descriptionParthenolide ≥98%
  • Packaging20mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS020015
  • Product description(-)-Parthenolide 97%
  • Packaging250mg
  • Price$56
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-P0297-M025 Parthenolide ≥98%(HPLC) 25mg $59 2021-12-16 Buy
AK Scientific V0355 Parthenolide 200mg $144 2021-12-16 Buy
American Custom Chemicals Corporation INB0000298 PARTHENOLIDE 95.00% 25MG $150.15 2021-12-16 Buy
American Custom Chemicals Corporation INB0000298 PARTHENOLIDE 95.00% 100MG $642.99 2021-12-16 Buy
ApexBio Technology N1315 Parthenolide 1unit $28 2021-12-16 Buy
ApexBio Technology N1315 Parthenolide 50mg $50 2021-12-16 Buy
ApexBio Technology N1315 Parthenolide 100mg $65 2021-12-16 Buy
ApexBio Technology N1315 Parthenolide 10mM(in 1mL DMSO) $80 2021-12-16 Buy
ApexBio Technology N1315 Parthenolide 250mg $140 2021-12-16 Buy
Apolloscientific BIP0110 Parthenolide 50mg $73 2021-12-16 Buy
Apolloscientific BIP0110 Parthenolide 100mg $116 2021-12-16 Buy
Apolloscientific BIP0110 Parthenolide 250mg $254 2021-12-16 Buy
Arctom AS020015 (-)-Parthenolide 97% 50mg $30 2021-12-16 Buy
Arctom AS020015 (-)-Parthenolide 97% 100mg $38 2021-12-16 Buy
Arctom CFN98034 Parthenolide ≥98% 20mg $40 2021-12-16 Buy
Arctom AS020015 (-)-Parthenolide 97% 250mg $56 2021-12-16 Buy

Properties

Melting point :115-116 °C (lit.)
alpha :D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)
Boiling point :394.1±42.0 °C(Predicted)
Density :1.13±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml)
form :White solid
color :White
Merck :14,7048
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
InChIKey :KTEXNACQROZXEV-PVLRGYAZSA-N
SMILES :O1C(=O)C(=C)[C@]2([H])CCC(C)=CCC[C@@]3(C)O[C@]3([H])[C@@]12[H] |t:10|
LogP :2.424 (est)
CAS DataBase Reference :20554-84-1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.

Description

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.

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