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ChemicalBook >> CAS DataBase List >> Onalespib

Onalespib

Onalespib price.
  • $33 - $1800
  • Product name: Onalespib
  • CAS: 912999-49-6
  • MF: C24H31N3O3
  • MW: 409.52
  • EINECS:
  • MDL Number:MFCD18633198
  • Synonyms:(2,4-dihydroxy-5-isopropylphenyl)(5-((4-Methylpiperazin-1-yl)Methyl)isoindolin-2-yl)Methanone;AT-13387;4-({5-[(4-Methylpiperazin-1-yl)Methyl]-2,3-dihydro-1H-isoindol-2-yl}carbonyl)-6-(propan-2-yl)benzene-1,3-diol;[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone;Onalespib;Onalespib (AT13387);[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone AT13387;AT13387, >=98%
30 prices
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Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 1mg
  • 2mg
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  • 10mg
  • 25mg
  • 50mg
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  • 250mg
  • 1g
  • 10g
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging1mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging25mg
  • Price$111
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging50mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging100mg
  • Price$251
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging250mg
  • Price$501
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA389427
  • Product description(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+%
  • Packaging1g
  • Price$1503
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0007159
  • Product descriptionAT-13387 95.00%
  • Packaging5MG
  • Price$459.8
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4056
  • Product descriptionAT13387
  • Packaging100mg
  • Price$1100
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60427
  • Product descriptionOnalespib(AT13387) ≥98%
  • Packaging10mg
  • Price$358
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA145338
  • Product descriptionAT-13387
  • Packaging2mg
  • Price$112.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA145338
  • Product descriptionAT-13387
  • Packaging5mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA145338
  • Product descriptionAT-13387
  • Packaging10g
  • Price$328
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA145338
  • Product descriptionAT-13387
  • Packaging25mg
  • Price$595
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA145338
  • Product descriptionAT-13387
  • Packaging50mg
  • Price$950
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 1mg $33 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 5mg $65 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 10mg $85 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 25mg $111 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 50mg $144 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 100mg $251 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 250mg $501 2021-12-16 Buy
Ambeed A389427 (2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone 98+% 1g $1503 2021-12-16 Buy
American Custom Chemicals Corporation API0007159 AT-13387 95.00% 5MG $459.8 2021-12-16 Buy
ApexBio Technology A4056 AT13387 100mg $1100 2021-12-16 Buy
Arctom CFN60427 Onalespib(AT13387) ≥98% 10mg $358 2021-12-16 Buy
Biosynth Carbosynth FA145338 AT-13387 2mg $112.8 2021-12-16 Buy
Biosynth Carbosynth FA145338 AT-13387 5mg $205 2021-12-16 Buy
Biosynth Carbosynth FA145338 AT-13387 10g $328 2021-12-16 Buy
Biosynth Carbosynth FA145338 AT-13387 25mg $595 2021-12-16 Buy
Biosynth Carbosynth FA145338 AT-13387 50mg $950 2021-12-16 Buy

Properties

Boiling point :605.7±55.0 °C(Predicted)
Density :1.237
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥13.25 mg/mL in DMSO; ≥47.7 mg/mL in EtOH with ultrasonic
form :solid
pka :8.50±0.48(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Onalespib, also known as AT13387, is a selective inhibitor of Hsp90 (IC50 = 18 nM). It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo. Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft models. It differs from other HSP90 inhibitors in its longer duration of target inhibition and its favorable toxicity profile in phase I studies in patients with refractory solid tumors.