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ChemicalBook >> CAS DataBase List >> NODULARIN

NODULARIN

NODULARIN price.
  • $138 - $2200
  • Product name: NODULARIN
  • CAS: 118399-22-7
  • MF: C41H60N8O10
  • MW: 824.96
  • EINECS:621-437-9
  • MDL Number:MFCD16659855
  • Synonyms:tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth ;yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl) ;NODULARIN;1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE;Nodularin, Nodularia spumigena;1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl);Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)
7 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 100μg
  • 100ug
  • 250μg
  • 1MG
  • 1ml
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0006050
  • Product descriptionCYCLO(3S-AMINO-9S-METHOXY-2S,6E,8S-TRIMETHYL-10-PHENYL-4,6-DECADIENOYL-D-GAMMA-GLUTAMYL-(2Z)-2-(METHYLAMINO)-2-BUTENOYL-(3S)-3-METHYL-D-BETA-ASPARTYL-L-ARGINYL) 95.00%
  • Packaging1MG
  • Price$1250.55
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10007190
  • Product descriptionNodularin ≥95%
  • Packaging100μg
  • Price$138
  • Updated2024-03-01
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number47934
  • Product descriptionNodularin
  • Packaging1mg
  • Price$2200
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberN5148
  • Product descriptionNodularin cyanotoxin
  • Packaging250μg
  • Price$638
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number32539
  • Product descriptionNodularin solution 10μg/mL in methanol, analytical standard
  • Packaging1ml
  • Price$590
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberN634260
  • Product descriptionNodularin
  • Packaging1mg
  • Price$1320
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number170023
  • Product descriptionNodularin
  • Packaging100ug
  • Price$325
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation CCH0006050 CYCLO(3S-AMINO-9S-METHOXY-2S,6E,8S-TRIMETHYL-10-PHENYL-4,6-DECADIENOYL-D-GAMMA-GLUTAMYL-(2Z)-2-(METHYLAMINO)-2-BUTENOYL-(3S)-3-METHYL-D-BETA-ASPARTYL-L-ARGINYL) 95.00% 1MG $1250.55 2021-12-16 Buy
Cayman Chemical 10007190 Nodularin ≥95% 100μg $138 2024-03-01 Buy
Medical Isotopes, Inc. 47934 Nodularin 1mg $2200 2021-12-16 Buy
Sigma-Aldrich N5148 Nodularin cyanotoxin 250μg $638 2024-03-01 Buy
Sigma-Aldrich 32539 Nodularin solution 10μg/mL in methanol, analytical standard 1ml $590 2024-03-01 Buy
TRC N634260 Nodularin 1mg $1320 2021-12-16 Buy
Usbiological 170023 Nodularin 100ug $325 2021-12-16 Buy

Properties

Density :1.29±0.1 g/cm3(Predicted)
Flash point :11℃
storage temp. :−20°C
solubility :methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
form :Dry residue containing traces of monobasic potassium phosphate.
pka :3.39±0.70(Predicted)
IARC :3 (Vol. 94) 2010
EPA Substance Registry System :Nodularin (118399-22-7)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.

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