MITHRAMYCIN A
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- $49 - $923
- Product name: MITHRAMYCIN A
- CAS: 18378-89-7
- MF: C52H76O24
- MW: 1085.15
- EINECS:634-048-4
- MDL Number:MFCD00135618
- Synonyms:AUREOLIC ACID;METHRAMYCIN A;MITHRAMYCIN A, FOR FLUORESCENCE;MITHRAMYCIN A FROM STREPTOMYCES*PLICATUS APPROX. 96;MITHRAMYCIN COMPLEX FROM STREPTOMYCES*PL ICATUS;MITHRAMYCIN FROM STREPTOMYCES PLICATUS;MITHRACIN;MITHRAMYCIN A
17 prices
Selected condition：
Brand
- Alfa Aesar
- ApexBio Technology
- Apolloscientific
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 2mg
- 25mg
- 1
- 1mg
- 5mg
- 1ml
- ManufacturerAlfa Aesar
- Product numberJ67319
- Product descriptionPlicamycin, 1 mg/ml in DMSO, sterile-filtered
- Packaging1ml
- Price$268
- Updated2023-06-20
- Buy
- ManufacturerApexBio Technology
- Product numberA4546
- Product descriptionMithramycinA
- Packaging5mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIM1003
- Product descriptionMithramycinAfromStreptomycesargillaceus
- Packaging1mg
- Price$73
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIM1003
- Product descriptionMithramycinAfromStreptomycesargillaceus
- Packaging5mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIM1003
- Product descriptionMithramycinAfromStreptomycesargillaceus
- Packaging25mg
- Price$923
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545970
- Product descriptionMithramycin A >98%
- Packaging1mg
- Price$136
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545970
- Product descriptionMithramycin A >98%
- Packaging5mg
- Price$323
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11434
- Product descriptionMithramycin A ≥98%
- Packaging5mg
- Price$190
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11434
- Product descriptionMithramycin A ≥98%
- Packaging1mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0014261
- Product descriptionPlicamycin >99.0%
- Packaging1mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0014261
- Product descriptionPlicamycin >99.0%
- Packaging5mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberM6891
- Product descriptionMithramycin A from Streptomyces plicatus ≥90% (HPLC)
- Packaging5mg
- Price$855
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberM6891
- Product descriptionMithramycin A from Streptomyces plicatus ≥90% (HPLC)
- Packaging1mg
- Price$204
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number5.30310
- Product descriptionMithramycin A - CAS 18378-89-7 - Calbiochem
- Packaging2mg
- Price$166
- Updated2022-05-15
- Buy
- ManufacturerTocris
- Product number1489
- Product descriptionMithramycinA ≥95%(HPLC)
- Packaging1
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberM369500
- Product descriptionMithramycinA
- Packaging1mg
- Price$65
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Alfa Aesar | J67319 | Plicamycin, 1 mg/ml in DMSO, sterile-filtered | 1ml | $268 | 2023-06-20 | Buy |
| ApexBio Technology | A4546 | MithramycinA | 5mg | $189 | 2021-12-16 | Buy |
| Apolloscientific | BIM1003 | MithramycinAfromStreptomycesargillaceus | 1mg | $73 | 2021-12-16 | Buy |
| Apolloscientific | BIM1003 | MithramycinAfromStreptomycesargillaceus | 5mg | $240 | 2021-12-16 | Buy |
| Apolloscientific | BIM1003 | MithramycinAfromStreptomycesargillaceus | 25mg | $923 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545970 | Mithramycin A >98% | 1mg | $136 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545970 | Mithramycin A >98% | 5mg | $323 | 2021-12-16 | Buy |
| Cayman Chemical | 11434 | Mithramycin A ≥98% | 5mg | $190 | 2024-03-01 | Buy |
| Cayman Chemical | 11434 | Mithramycin A ≥98% | 1mg | $49 | 2024-03-01 | Buy |
| ChemScene | CS-0014261 | Plicamycin >99.0% | 1mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-0014261 | Plicamycin >99.0% | 5mg | $240 | 2021-12-16 | Buy |
| Sigma-Aldrich | M6891 | Mithramycin A from Streptomyces plicatus ≥90% (HPLC) | 5mg | $855 | 2024-03-01 | Buy |
| Sigma-Aldrich | M6891 | Mithramycin A from Streptomyces plicatus ≥90% (HPLC) | 1mg | $204 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.30310 | Mithramycin A - CAS 18378-89-7 - Calbiochem | 2mg | $166 | 2022-05-15 | Buy |
| Tocris | 1489 | MithramycinA ≥95%(HPLC) | 1 | $119 | 2021-12-16 | Buy |
| TRC | M369500 | MithramycinA | 1mg | $65 | 2021-12-16 | Buy |
Properties
Melting point :180-183 °C
alpha :D20 -51° (c = 0.4 in ethanol)
Boiling point :761.72°C (rough estimate)
Density :1.1576 (rough estimate)
refractive index :1.6500 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml)
form :Powder
pka :4.54±0.60(Predicted)
color :Red to brown
Merck :13,7619
BRN :5236667
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
EPA Substance Registry System :Plicamycin (18378-89-7)
alpha :D20 -51° (c = 0.4 in ethanol)
Boiling point :761.72°C (rough estimate)
Density :1.1576 (rough estimate)
refractive index :1.6500 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml)
form :Powder
pka :4.54±0.60(Predicted)
color :Red to brown
Merck :13,7619
BRN :5236667
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
EPA Substance Registry System :Plicamycin (18378-89-7)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic originally isolated from S. grieseus that has long been used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or transcription factors and, thereby, chromatin accessibility to transcriptional machinery. As a selective Sp1 inhibitor, mithramycin A binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, which inhibits their expression. Mithramycin A (at 10-200 nM) can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many different cancer models.Related product price
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