LDN-214117
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- $30 - $870
- Product name: LDN-214117
- CAS: 1627503-67-6
- MF: C25H29N3O3
- MW: 419.52
- EINECS:
- MDL Number:MFCD28168043
- Synonyms:LDN-214117;1-(4-(6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine;1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine;LDN-214117;LDN214117;CS-1539;Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-;LDN-214117 USP/EP/BP;LDN214117,LDN-214117,ALK2,BMP4,BMP2,Transforming growth factor beta receptors,LDN 214117,BMP6,TGF-β Receptor,diffuse intrinsic pontine glioma(DIPG),oral,ALK3,fibrodysplasia ossificans progressiva (FOP),ALK5,type I receptor kinases,ALK1,bone morphogenetic proteins (BMPs)
26 prices
Selected condition：
Brand
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
- TRC
Package
- 10
- 1mg
- 5mg
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAmbeed
- Product numberA637146
- Product descriptionLDN-214117 98+%
- Packaging1mg
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA637146
- Product descriptionLDN-214117 98+%
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA637146
- Product descriptionLDN-214117 98+%
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA637146
- Product descriptionLDN-214117 98+%
- Packaging50mg
- Price$315
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA637146
- Product descriptionLDN-214117 98+%
- Packaging100mg
- Price$495
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002514
- Product description1-(4-(6-METHYL-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL)PHENYL)PIPERAZINE 95.00%
- Packaging5MG
- Price$496.93
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4842
- Product descriptionLDN-214117
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4842
- Product descriptionLDN-214117
- Packaging25mg
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4842
- Product descriptionLDN-214117
- Packaging100mg
- Price$595
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18006
- Product descriptionLDN-214117 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18006
- Product descriptionLDN-214117 ≥98%
- Packaging5mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18006
- Product descriptionLDN-214117 ≥98%
- Packaging10mg
- Price$184
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18006
- Product descriptionLDN-214117 ≥98%
- Packaging25mg
- Price$381
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3539
- Product descriptionLDN-214117 99.95%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3539
- Product descriptionLDN-214117 99.95%
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3539
- Product descriptionLDN-214117 99.95%
- Packaging25mg
- Price$220
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A637146 | LDN-214117 98+% | 1mg | $30 | 2021-12-16 | Buy |
| Ambeed | A637146 | LDN-214117 98+% | 5mg | $50 | 2021-12-16 | Buy |
| Ambeed | A637146 | LDN-214117 98+% | 10mg | $90 | 2021-12-16 | Buy |
| Ambeed | A637146 | LDN-214117 98+% | 50mg | $315 | 2021-12-16 | Buy |
| Ambeed | A637146 | LDN-214117 98+% | 100mg | $495 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002514 | 1-(4-(6-METHYL-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL)PHENYL)PIPERAZINE 95.00% | 5MG | $496.93 | 2021-12-16 | Buy |
| ApexBio Technology | B4842 | LDN-214117 | 5mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | B4842 | LDN-214117 | 25mg | $245 | 2021-12-16 | Buy |
| ApexBio Technology | B4842 | LDN-214117 | 100mg | $595 | 2021-12-16 | Buy |
| Cayman Chemical | 18006 | LDN-214117 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18006 | LDN-214117 ≥98% | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 18006 | LDN-214117 ≥98% | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 18006 | LDN-214117 ≥98% | 25mg | $381 | 2024-03-01 | Buy |
| ChemScene | CS-3539 | LDN-214117 99.95% | 5mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-3539 | LDN-214117 99.95% | 10mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-3539 | LDN-214117 99.95% | 25mg | $220 | 2021-12-16 | Buy |
Properties
Boiling point :567.9±50.0 °C(Predicted)
Density :1.134±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF:30.0(Max Conc. mg/mL);71.51(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM)
DMSO:42.67(Max Conc. mg/mL);101.7(Max Conc. mM)
Ethanol:54.0(Max Conc. mg/mL);128.72(Max Conc. mM) pka :8.86±0.10(Predicted)
form :Powder
color :Light yellow to yellow
Density :1.134±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF:30.0(Max Conc. mg/mL);71.51(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM)
DMSO:42.67(Max Conc. mg/mL);101.7(Max Conc. mM)
Ethanol:54.0(Max Conc. mg/mL);128.72(Max Conc. mM) pka :8.86±0.10(Predicted)
form :Powder
color :Light yellow to yellow
Safety Information
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Description
Bone morphogenetic proteins (BMPs) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation. Activation of BMP type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. LDN-214117 is a selective BMP type I receptor kinase ALK1 and ALK2 inhibitor (IC50s = 24 nM for each). It demonstrates preference for ALK1 and ALK2 over ALK3 (IC50 = 1.17 μM) and other related activin and TGF-β type I receptors (IC50s = 3, 0.1, and 16 μM for ALK5, BMP6, and TGF-β, respectively).Related product price
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