K 02288
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- $37 - $1700
- Product name: K 02288
- CAS: 1431985-92-0
- MF: C20H20N2O4
- MW: 352.38
- EINECS:
- MDL Number:MFCD26936347
- Synonyms:LM-3151 K02288;K 02288;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;K 02288 Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-;K02288 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;K 02288(K 02288a);K 02288a;K 02288 USP/EP/BP
24 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10
- 1mg
- 50
- 10mg
- 10mM(in 1mL DMSO)
- 25MG
- 50mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberY1876
- Product descriptionK02288
- Packaging10mg
- Price$243
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1876
- Product descriptionK02288
- Packaging50mg
- Price$771
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151373
- Product description3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+%
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151373
- Product description3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+%
- Packaging10mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151373
- Product description3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+%
- Packaging50mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2286
- Product descriptionK02288
- Packaging10mM(in 1mL DMSO)
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2286
- Product descriptionK02288
- Packaging50mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16678
- Product descriptionK02288 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16678
- Product descriptionK02288 ≥98%
- Packaging5mg
- Price$134
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16678
- Product descriptionK02288 ≥98%
- Packaging10mg
- Price$231
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16678
- Product descriptionK02288 ≥98%
- Packaging50mg
- Price$793
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM249406
- Product description3-(6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol 98%
- Packaging50mg
- Price$404
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3395
- Product descriptionK02288 99.80%
- Packaging10mg
- Price$162
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3395
- Product descriptionK02288 99.80%
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003498
- Product descriptionK02288 98+%
- Packaging50mg
- Price$461
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7742
- Product descriptionK02288 >98%
- Packaging250mg
- Price$800
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y1876 | K02288 | 10mg | $243 | 2021-12-16 | Buy |
| AK Scientific | Y1876 | K02288 | 50mg | $771 | 2021-12-16 | Buy |
| Ambeed | A151373 | 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+% | 5mg | $50 | 2021-12-16 | Buy |
| Ambeed | A151373 | 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+% | 10mg | $65 | 2021-12-16 | Buy |
| Ambeed | A151373 | 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+% | 50mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | B2286 | K02288 | 10mM(in 1mL DMSO) | $149 | 2021-12-16 | Buy |
| ApexBio Technology | B2286 | K02288 | 50mg | $450 | 2021-12-16 | Buy |
| Cayman Chemical | 16678 | K02288 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16678 | K02288 ≥98% | 5mg | $134 | 2024-03-01 | Buy |
| Cayman Chemical | 16678 | K02288 ≥98% | 10mg | $231 | 2024-03-01 | Buy |
| Cayman Chemical | 16678 | K02288 ≥98% | 50mg | $793 | 2024-03-01 | Buy |
| Chemenu | CM249406 | 3-(6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol 98% | 50mg | $404 | 2021-12-16 | Buy |
| ChemScene | CS-3395 | K02288 99.80% | 10mg | $162 | 2021-12-16 | Buy |
| ChemScene | CS-3395 | K02288 99.80% | 50mg | $540 | 2021-12-16 | Buy |
| Crysdot | CD31003498 | K02288 98+% | 50mg | $461 | 2021-12-16 | Buy |
| DC Chemicals | DC7742 | K02288 >98% | 250mg | $800 | 2021-12-16 | Buy |
Properties
Melting point :201-203°C
Boiling point :522.2±50.0 °C(Predicted)
Density :1.232±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.33±0.10(Predicted)
form :powder
color :white to beige
Boiling point :522.2±50.0 °C(Predicted)
Density :1.232±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.33±0.10(Predicted)
form :powder
color :white to beige
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.More related product prices
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