GNF 5837
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- $24 - $1802
- Product name: GNF 5837
- CAS: 1033769-28-6
- MF: C28H21F4N5O2
- MW: 535.49
- EINECS:
- MDL Number:MFCD24386809
- Synonyms:Trk Inhibitor III, GNF-5837 ;GNF 5837;(Z)-1-(3-(3-((1H-PYRROL-2-YL)METHYLENE)-2-OXOINDOLIN-6-YLAMINO)-4-METHYLPHENYL)-3-(2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL)UREA;N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea;GNF 5837 N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea;N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea GNF5837;GNF-5837, >=98%;1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-(4-methyl-3-{[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]amino}phenyl)urea
41 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10
- 1mg
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- 1000mg
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1183-M010
- Product descriptionGNF 5837 ≥95%
- Packaging10mg
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2435AH
- Product descriptionN-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea
- Packaging10mg
- Price$199
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2435AH
- Product descriptionN-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea
- Packaging100mg
- Price$771
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA638163
- Product descriptionGNF 5837 98+%
- Packaging1mg
- Price$24
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA638163
- Product descriptionGNF 5837 98+%
- Packaging5mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA638163
- Product descriptionGNF 5837 98+%
- Packaging10mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA638163
- Product descriptionGNF 5837 98+%
- Packaging50mg
- Price$198
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA638163
- Product descriptionGNF 5837 98+%
- Packaging100mg
- Price$333
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA638163
- Product descriptionGNF 5837 98+%
- Packaging250mg
- Price$666
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA638163
- Product descriptionGNF 5837 98+%
- Packaging1g
- Price$1663
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8303
- Product descriptionGNF 5837
- Packaging10mM(in 1mL DMSO)
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8303
- Product descriptionGNF 5837
- Packaging10mg
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8303
- Product descriptionGNF 5837
- Packaging50mg
- Price$278
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8303
- Product descriptionGNF 5837
- Packaging200mg
- Price$670
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181007
- Product descriptionGNF 5837 >98%
- Packaging100mg
- Price$542.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181007
- Product descriptionGNF 5837 >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1183-M010 | GNF 5837 ≥95% | 10mg | $216 | 2021-12-16 | Buy |
| AK Scientific | 2435AH | N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea | 10mg | $199 | 2021-12-16 | Buy |
| AK Scientific | 2435AH | N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea | 100mg | $771 | 2021-12-16 | Buy |
| Ambeed | A638163 | GNF 5837 98+% | 1mg | $24 | 2021-12-16 | Buy |
| Ambeed | A638163 | GNF 5837 98+% | 5mg | $41 | 2021-12-16 | Buy |
| Ambeed | A638163 | GNF 5837 98+% | 10mg | $72 | 2021-12-16 | Buy |
| Ambeed | A638163 | GNF 5837 98+% | 50mg | $198 | 2021-12-16 | Buy |
| Ambeed | A638163 | GNF 5837 98+% | 100mg | $333 | 2021-12-16 | Buy |
| Ambeed | A638163 | GNF 5837 98+% | 250mg | $666 | 2021-12-16 | Buy |
| Ambeed | A638163 | GNF 5837 98+% | 1g | $1663 | 2021-12-16 | Buy |
| ApexBio Technology | A8303 | GNF 5837 | 10mM(in 1mL DMSO) | $95 | 2021-12-16 | Buy |
| ApexBio Technology | A8303 | GNF 5837 | 10mg | $103 | 2021-12-16 | Buy |
| ApexBio Technology | A8303 | GNF 5837 | 50mg | $278 | 2021-12-16 | Buy |
| ApexBio Technology | A8303 | GNF 5837 | 200mg | $670 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181007 | GNF 5837 >98% | 100mg | $542.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181007 | GNF 5837 >98% | 250mg | $912.9 | 2021-12-16 | Buy |
Properties
Melting point :>228°C (dec.)
Boiling point :616.0±55.0 °C(Predicted)
Density :1.497±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :12.16±0.20(Predicted)
form :powder
color :yellow to orange
Boiling point :616.0±55.0 °C(Predicted)
Density :1.497±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :12.16±0.20(Predicted)
form :powder
color :yellow to orange
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Tropomyosin-related kinases (Trks) are receptor tyrosine kinases activated by peptides, including neurotrophins. They have prominent roles in the development of central and peripheral nervous systems, vascular cell survival, and cancer. Rearrangement of genes for Trks with the transcription factor Tel, producing Tel-Trk fusion proteins, are associated with various types of cancer. GNF-5837 is a potent, bioavailable pan-Trk inhibitor that blocks the proliferation of cells expressing Tel-TrkA, Tel-TrkB, and Tel-TrkC (IC50s = 7, 9, and 11 nM, respectively). It less effectively inhibits c-Kit and PDGFRβ (IC50s = 0.91 and 0.87 μM, respectively), while requiring micromolar concentrations to inhibit an array of other receptor and non-receptor tyrosine kinases. GNF-5837 inhibits the growth of Ba/F3 and rat intestinal epithelial (RIE) cells expressing both TrkA and nerve growth factor (NGF) with IC50 values of 42 and 17 nM, respectively, but does not have anti-proliferative activity of parental cells at concentrations up to 10 μM. GNF-5837 displays good bioavailability in mice and rats when given intravenously but not orally. It induces regression of tumor xenografts derived from RIE cells expressing both TrkA and NGF.More related product prices
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