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ChemicalBook >> CAS DataBase List >> FLUTICASONE FUROATE

FLUTICASONE FUROATE

FLUTICASONE FUROATE price.
  • $32 - $1800
  • Product name: FLUTICASONE FUROATE
  • CAS: 397864-44-7
  • MF: C27H29F3O6S
  • MW: 538.58
  • EINECS:222-789-2
  • MDL Number:MFCD09954122
  • Synonyms:FLUTICASONE FUROATE;Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-((2- furanylcarbonyl)oxy)-11-hydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6alpha,11beta,16alpha,17alpha)-;Gw 685698x;Unii-js86977wnv;Veramyst;(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid S-(FluoroMethyl) Ester;AllerMist;GSK 685 698
12 prices
Selected condition:
Brand
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50MG
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006841
  • Product descriptionFLUTICASONE FUROATE-D3 95.00%
  • Packaging5MG
  • Price$495.1
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29878
  • Product descriptionFluticasone Furoate
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29878
  • Product descriptionFluticasone Furoate
  • Packaging5mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29878
  • Product descriptionFluticasone Furoate
  • Packaging10mg
  • Price$199
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29878
  • Product descriptionFluticasone Furoate
  • Packaging25mg
  • Price$343
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0003822
  • Product descriptionFluticasonefuroate 99.06%
  • Packaging10mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10020
  • Product descriptionFluticasonefuroate >98%
  • Packaging100mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10020
  • Product descriptionFluticasonefuroate >98%
  • Packaging250mg
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10020
  • Product descriptionFluticasonefuroate >98%
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML3103
  • Product descriptionFluticasone furoate ≥98% (HPLC)
  • Packaging10MG
  • Price$89
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML3103
  • Product descriptionFluticasone furoate ≥98% (HPLC)
  • Packaging50MG
  • Price$359
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberF599510
  • Product descriptionFluticasoneFuroate
  • Packaging25mg
  • Price$730
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation RDL0006841 FLUTICASONE FUROATE-D3 95.00% 5MG $495.1 2021-12-16 Buy
Cayman Chemical 29878 Fluticasone Furoate 1mg $32 2024-03-01 Buy
Cayman Chemical 29878 Fluticasone Furoate 5mg $116 2024-03-01 Buy
Cayman Chemical 29878 Fluticasone Furoate 10mg $199 2024-03-01 Buy
Cayman Chemical 29878 Fluticasone Furoate 25mg $343 2024-03-01 Buy
ChemScene CS-0003822 Fluticasonefuroate 99.06% 10mg $55 2021-12-16 Buy
DC Chemicals DC10020 Fluticasonefuroate >98% 100mg $500 2021-12-16 Buy
DC Chemicals DC10020 Fluticasonefuroate >98% 250mg $900 2021-12-16 Buy
DC Chemicals DC10020 Fluticasonefuroate >98% 1g $1800 2021-12-16 Buy
Sigma-Aldrich SML3103 Fluticasone furoate ≥98% (HPLC) 10MG $89 2024-03-01 Buy
Sigma-Aldrich SML3103 Fluticasone furoate ≥98% (HPLC) 50MG $359 2024-03-01 Buy
TRC F599510 FluticasoneFuroate 25mg $730 2021-12-16 Buy

Properties

Melting point :250-252°C (dec.)
Boiling point :625.2±55.0 °C(Predicted)
Density :1.39
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)
pka :12.52±0.70(Predicted)
form :Solid
color :White to Off-White
InChIKey :XTULMSXFIHGYFS-XEVZMEAZNA-N
SMILES :[C@]12(C)C=CC(=O)C=C1[C@@H](F)C[C@@]1([H])[C@]3([H])C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)C4=CC=CO4)[C@@]3(C)C[C@H](O)[C@]21F |&1:0,8,11,13,16,18,32,35,37,r|

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Fluticasone furoate is a new corticosteroid derivative launched as a nasal spray for the treatment of seasonal and perennial allergic rhinitis in adults and in children aged ≥2 years. It is structurally closely related to the previously marketed intranasal corticosteroid fluticasone propionate (FP). Both of these steroids contain the unusual S-fluoromethyl carbothioate group, which confers high lipophilicity and hence enhanced binding and retention of the drug by the nasal tissue. Additionally, the carbothioate group rapidly undergoes first-pass metabolism by CYP3A4, thus minimizing systemic exposure of the parent drug. Fluticasone furoate is a potent ligand for the glucocorticoid receptor (GR), with a relative receptor affinity (RRA) of 2,989 with reference to dexamethasone RRA of 100.
Following intranasal administration, most of the dose is eventually swallowed and undergoes incomplete absorption and extensive firstpass metabolism in the liver and gut, resulting in negligible systemic exposure. Pharmacokinetic studies using oral solution dosing and intravenous dosing show that at least 30% of fluticasone furoate is absorbed and then rapidly cleared from plasma. The most common adverse reactions (W1% incidence) included headache, epistatix, sinus and throat pain, nasal ulceration, back pain, pyrexia, and cough. Fluticasone furoate is chemically derived starting from a readily available corticosteroid, 6a,9a-difluoro-11b,17a-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17b-carboxylic acid, by first converting the carboxylic acid group to the corresponding carbothioic acid via activation with carbonyl diimidazole followed by reaction with hydrogen sulfide gas. Subsequently, selective acylation of the 17a-hydroxyl group with 2-furoyl chloride and alkylation of the 17b-carbothioic acid group with bromofluoromethane under basic conditions provides fluticasone furoate.