FLUTICASONE FUROATE
- $32 - $1800
- Product name: FLUTICASONE FUROATE
- CAS: 397864-44-7
- MF: C27H29F3O6S
- MW: 538.58
- EINECS:222-789-2
- MDL Number:MFCD09954122
- Synonyms:FLUTICASONE FUROATE;Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-((2- furanylcarbonyl)oxy)-11-hydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6alpha,11beta,16alpha,17alpha)-;Gw 685698x;Unii-js86977wnv;Veramyst;(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid S-(FluoroMethyl) Ester;AllerMist;GSK 685 698
12 prices
Selected condition:
Brand
- American Custom Chemicals Corporation
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50MG
- 100mg
- 250mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberRDL0006841
- Product descriptionFLUTICASONE FUROATE-D3 95.00%
- Packaging5MG
- Price$495.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29878
- Product descriptionFluticasone Furoate
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29878
- Product descriptionFluticasone Furoate
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29878
- Product descriptionFluticasone Furoate
- Packaging10mg
- Price$199
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29878
- Product descriptionFluticasone Furoate
- Packaging25mg
- Price$343
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0003822
- Product descriptionFluticasonefuroate 99.06%
- Packaging10mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10020
- Product descriptionFluticasonefuroate >98%
- Packaging100mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10020
- Product descriptionFluticasonefuroate >98%
- Packaging250mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10020
- Product descriptionFluticasonefuroate >98%
- Packaging1g
- Price$1800
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML3103
- Product descriptionFluticasone furoate ≥98% (HPLC)
- Packaging10MG
- Price$89
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML3103
- Product descriptionFluticasone furoate ≥98% (HPLC)
- Packaging50MG
- Price$359
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberF599510
- Product descriptionFluticasoneFuroate
- Packaging25mg
- Price$730
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
American Custom Chemicals Corporation | RDL0006841 | FLUTICASONE FUROATE-D3 95.00% | 5MG | $495.1 | 2021-12-16 | Buy |
Cayman Chemical | 29878 | Fluticasone Furoate | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 29878 | Fluticasone Furoate | 5mg | $116 | 2024-03-01 | Buy |
Cayman Chemical | 29878 | Fluticasone Furoate | 10mg | $199 | 2024-03-01 | Buy |
Cayman Chemical | 29878 | Fluticasone Furoate | 25mg | $343 | 2024-03-01 | Buy |
ChemScene | CS-0003822 | Fluticasonefuroate 99.06% | 10mg | $55 | 2021-12-16 | Buy |
DC Chemicals | DC10020 | Fluticasonefuroate >98% | 100mg | $500 | 2021-12-16 | Buy |
DC Chemicals | DC10020 | Fluticasonefuroate >98% | 250mg | $900 | 2021-12-16 | Buy |
DC Chemicals | DC10020 | Fluticasonefuroate >98% | 1g | $1800 | 2021-12-16 | Buy |
Sigma-Aldrich | SML3103 | Fluticasone furoate ≥98% (HPLC) | 10MG | $89 | 2024-03-01 | Buy |
Sigma-Aldrich | SML3103 | Fluticasone furoate ≥98% (HPLC) | 50MG | $359 | 2024-03-01 | Buy |
TRC | F599510 | FluticasoneFuroate | 25mg | $730 | 2021-12-16 | Buy |
Properties
Melting point :250-252°C (dec.)
Boiling point :625.2±55.0 °C(Predicted)
Density :1.39
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)
pka :12.52±0.70(Predicted)
form :Solid
color :White to Off-White
InChIKey :XTULMSXFIHGYFS-XEVZMEAZNA-N
SMILES :[C@]12(C)C=CC(=O)C=C1[C@@H](F)C[C@@]1([H])[C@]3([H])C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)C4=CC=CO4)[C@@]3(C)C[C@H](O)[C@]21F |&1:0,8,11,13,16,18,32,35,37,r|
Boiling point :625.2±55.0 °C(Predicted)
Density :1.39
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)
pka :12.52±0.70(Predicted)
form :Solid
color :White to Off-White
InChIKey :XTULMSXFIHGYFS-XEVZMEAZNA-N
SMILES :[C@]12(C)C=CC(=O)C=C1[C@@H](F)C[C@@]1([H])[C@]3([H])C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)C4=CC=CO4)[C@@]3(C)C[C@H](O)[C@]21F |&1:0,8,11,13,16,18,32,35,37,r|
Safety Information
Symbol(GHS): | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | ||||||||||||
Hazard statements: |
|
||||||||||||
Precautionary statements: |
|
Description
Fluticasone furoate is a new corticosteroid derivative launched as a nasal spray for the treatment of seasonal and perennial allergic rhinitis in adults and in children aged ≥2 years. It is structurally closely related to the previously marketed intranasal corticosteroid fluticasone propionate (FP). Both of these steroids contain the unusual S-fluoromethyl carbothioate group, which confers high lipophilicity and hence enhanced binding and retention of the drug by the nasal tissue. Additionally, the carbothioate group rapidly undergoes first-pass metabolism by CYP3A4, thus minimizing systemic exposure of the parent drug. Fluticasone furoate is a potent ligand for the glucocorticoid receptor (GR), with a relative receptor affinity (RRA) of 2,989 with reference to dexamethasone RRA of 100.Following intranasal administration, most of the dose is eventually swallowed and undergoes incomplete absorption and extensive firstpass metabolism in the liver and gut, resulting in negligible systemic exposure. Pharmacokinetic studies using oral solution dosing and intravenous dosing show that at least 30% of fluticasone furoate is absorbed and then rapidly cleared from plasma. The most common adverse reactions (W1% incidence) included headache, epistatix, sinus and throat pain, nasal ulceration, back pain, pyrexia, and cough. Fluticasone furoate is chemically derived starting from a readily available corticosteroid, 6a,9a-difluoro-11b,17a-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17b-carboxylic acid, by first converting the carboxylic acid group to the corresponding carbothioic acid via activation with carbonyl diimidazole followed by reaction with hydrogen sulfide gas. Subsequently, selective acylation of the 17a-hydroxyl group with 2-furoyl chloride and alkylation of the 17b-carbothioic acid group with bromofluoromethane under basic conditions provides fluticasone furoate.
Related product price
- 16a(R),17-(Butylidenebis(oxy))-11b,21-dihydroxypregna-1,4-diene-3,20-dione
$185-2800 - BECLOMETHASONE
$39-2590 - Flumethasone
$35-1683
Suppliers and manufacturers
Protheragen-ING
Henan Tianfu Chemical Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
Lianyungang happen teng technology co., LTD
SHANDONG ZHI SHANG CHEMICAL CO.LTD
BOC Sciences
TopScience Biochemical